左氧氟沙星联合碳酸氢钠预防伊立替康导致的延迟性腹泻  

Levofloxacin Combined with Sodium Bicarbonate for Prevention of Irinotecan-induced Diarrhea

作　　者：匡薇[1] 肖琦[2] 

机构地区：[1]泰和县人民医院药剂科,江西泰和343700 [2]南昌大学第一附属医院普外科,南昌330006

出　　处：《实用临床医学（江西）》2011年第7期22-24,共3页Practical Clinical Medicine

摘　　要：目的观察左氧氟沙星联合碳酸氢钠预防伊立替康导致的延迟性腹泻的疗效。方法将30例接受伊立替康方案化疗的晚期癌症患者按随机数字表法分为A、B 2组,每组15例。A组接受伊立替康方案化疗71周,在化疗前1d口服左氧氟沙星0.1g,2次.d-1,碳酸氢钠片2g,3次.d-1,连用4d;B组接受伊立替康方案化疗53周,常规盐酸洛哌丁胺备用,并嘱避免进食奶制品、粗纤维食物、胡椒和咖啡等能导致腹泻食物。对2组总腹泻周数,1-2级、3-4级腹泻发生情况进行比较。结果 A组总腹泻周数为7周(9.8%,7/71),B组总腹泻周数为27周(50.9%,27/53),2组比较差异有统计学意义(P<0.01)。A组发生1-2级腹泻周期数为6周(8.5%,6/71),发生3-4级腹泻周期数为1周(1.4%,1/71);B组发生1-2级腹泻周期数为21周(39.6%,21/53),发生3-4级腹泻周期数为6周(11.2%,6/53),2组1-2级、3-4级腹泻周期所占百分率比较差异有统计学意义(P<0.05或P<0.01)。结论左氧氟沙星联合碳酸氢钠能有效预防伊立替康导致的延迟性腹泻。Objective To observe the therapeutic effects of Levofloxacin combined with sodium bicarbonate in irinotecan-induced diarrhea.Methods A total of 30 patients with advanced colorectal cancer were allocated into group A（n=15） and group B（n=15）.Patients in group A were treated with irinotecan chemotherapy for 71 weeks,and were given oral levofloxacin（0.1 g,2 times per day） and sodium bicarbonate tablets（2 g,3 times per day） for 4 days at 1 day before chemotherapy.Patients in group B were treated with irinotecan chemotherapy for 53 weeks（loperamide hydrochloride as a routine backup）,and were asked to avoid eating dairy products,crude fiber foods,pepper,coffee and other foods causing diarrhea.The total incidence of diarrhea and occurrences of grade 1-2 and grade 3-4 diarrhea were compared between the two groups.Results The duration of diarrhea,grade 1-2 diarrhea and grade 3-4 diarrhea in group A（7,6 and 1 weeks,respectively） was significantly shorter than that in group B（27,21 and 6 weeks,respectively）（P0.05 or P0.01）.Conclusion Levofloxacin combined with sodium bicarbonate is effective for the prevention of irinotecan-induced diarrhea.

关 键 词：伊立替康 碳酸氢钠 左氧氟沙星 盐酸洛哌丁胺 延迟性腹泻 

分 类 号：R979.1[医药卫生—药品] R73[医药卫生—药学]