碳酸钾催化酮亚胺的硅腈化反应研究  

Study on Cyanosilylation of Ketoimines Catalized by Potassium Carbonate

作　　者：黄靖伦[1] 张丽媛[1] 程碧波[1] 

机构地区：[1]中国工程物理研究院化工材料研究所,四川绵阳621900

出　　处：《精细化工中间体》2011年第3期32-35,共4页Fine Chemical Intermediates

基　　金：国家基础安全发展计划项目(973计划;613830101)

摘　　要：研究确定了反应的优化条件:碳酸钾用量为0.05(n/n),TMSCN用量为2.0(n/n),反应溶剂为无水甲醇,酮亚胺浓度为0.4 mol/L,反应温度为室温(25℃)。此优化条件下反应收率达91%～99%。α-Amino acids are essential to human.The products of cyanosilylation of ketoimines are the precursors of α,α-dialkyl amino acids.It is one of the cheapest and available methods to synthesize α-amino acids.Many factors affecting the cyanosilylation of ketoimines,including inorganic salts,solvent,concentration,loading of catalyst,were investigated and optimized.Under the conditions of 5%（mol） of K2CO3,2.0 equivalent of TMSCN,0.4 mol/L of ketoimine and temperature of 25℃ in methanol,the products were obtained in 91%~99% yield.

关 键 词：酮亚胺 碳酸钾 硅腈化 催化反应 

分 类 号：O643.36[理学—物理化学]