严重畸形精子症不同体外受精方式的对照研究  

Comparison between Different In-vitro Fertilizations in Patients with Severe Teratozoospermia

作　　者：甘贤优[1] 张波[1] 冯贵雪[1] 周红[1] 舒金辉[1] 

机构地区：[1]广西壮族自治区妇幼保健院生殖中心,南宁市530003

出　　处：《广西医学》2011年第8期948-950,共3页Guangxi Medical Journal

基　　金：广西医药卫生科学研究基金资助项目(Z2008197)

摘　　要：目的探讨不同受精方式对严重畸形精子症治疗结局的影响。方法严重畸形精子症患者87例,分别接受常规体外受精(IVF,n=46)和卵胞浆内单精子显微注射术(ICSI,n=41)治疗,比较两组间的卵母细胞受精率、卵裂率、优质胚胎率、临床妊娠率和早期流产率。结果 IVF组卵母细胞受精率达到68.48%,但显著低于ICSI组(P<0.01);IVF组优质胚胎率显著高于ICSI组(P<0.01);两组临床妊娠率和早期流产率差异无统计学意义(P>0.05)。结论 ICSI并非严重畸形精子症患者的唯一助孕方式,临床上应结合精子浓度、活力和其他精子形态参数来选择合适的治疗方式。Objective To compare the effects of conventional in-vitro fertilization versus intracytoplasmic sperm injection in cases of severe teratozoospermia.Methods 87 cases of severe teratozoospermia were divided into two groups,and treated by conventional in-vitro fertilization（IVF group,n=46）or intracytoplasmic sperm injection（ICSI group,n=41）respectively.The fertilization rate,cleavage rate,high-quality embryo rate,pregnancy rate and early abortion rate were compared between the two groups.Results The fertilization rate of IVF group was significantly lower than that of ICSI group（68.48% vs 81.95%,P0.01）;The high-quality embryo rate of IVF group was significantly higher than that of ICSI group（61.23% vs 48.11%,P0.01）;There was no statistical difference in pregnancy rate and early abortion rate between the two groups（P0.05）.Conclusion For patients with severe teratozoospermia,ICSI is not the only choice,combining the sperm concentration,motility and other morphology parameters to select the appropriate treatment method.

关 键 词：畸形精子症 精子形态 体外受精 卵胞浆内单精子显微注射 

分 类 号：R698.2[医药卫生—泌尿科学]