氯胺酮对体外循环心脏病患儿血浆NSE和S100β蛋白的影响  

Effects of Ketamine on Concentration of NSE and S100β in Plasma after Cardiopulmonary Bypass in Infants with Heart Disease

作　　者：王鹏高[1] 陈忠建[1] 董向阳[1] 和东阳[1] 李基伟[1] 翟波[1] 

机构地区：[1]郑州市儿童医院心胸外科,河南郑州450053

出　　处：《中国现代医生》2011年第22期51-52,共2页China Modern Doctor

摘　　要：目的研究氯胺酮(Ketamine)在婴幼儿体外循环手术患者血浆神经元特异性烯醇化酶(NSE)和S100β蛋白的影响。方法选择28例拟在CPB下行室间隔缺损的婴幼儿患者,随机分为两组各14例。氯胺酮组(K组)转流前经中心静脉泵入氯胺酮1mg/kg;对照组(C组)给予等量平衡液。分别于转流前和转流完毕时从中心静脉采血,使用ELISA法测定血浆NSE和S100β蛋白的浓度。结果①与转流前相比,转流后C组NSE和S100β含量均明显升高(P<0.05);②组间比较,转流前两组的NSE和S100β含量变化不明显,转流后C组NSE和S100β含量明显高于K组(P<0.05)。结论氯胺酮的应用可减少婴幼儿CPB术后血浆NSE和S100β蛋白的释放,从而对脑损伤起到保护作用。Objective To investigate the effects of ketamine on plasma NSE and S100 β in plasma after cardiopulmonary bypass （ CPB ） in infants. Methods Twenty-eight patients for repair of ventricular septal defect （ VSD ） were randomly divided into two groups： ketamine group （group K, n=14 ） received ketamine lmg/kg intravenously before CPB and control group （group C, n=14 ） received normal saline instead of Ketamine. Blood samples from external cycle were collected before start of CPB and after termination of CPB for determination of plasma NSE and S100 β concentration, respectively. Results In group C, the expression level of plasma NSE and S100 β significantly increased after CPB （ P 〈 0.05 ）. Meanwhile, there was no significant difference of the concentrations of NSE and S100 β between the two groups before start of CPB. After termination of CPB, the expression level of plasma NSE and S100β was obviously higher in group C than that in group K （P 〈 0.05 ）. Conclusion Ketamine can reduce the release of NSE and S100β protein in infants after CPB, so it may attenuate the brain injury.

关 键 词：氯胺酮 体外循环 NSE S100Β 

分 类 号：R654.1[医药卫生—外科学]