血栓抽吸后应用替罗非班对心肌再灌注的影响  

Effects of Thrombus Aspiration plus Administration of Tirofiban on Myocardial Reperfusion in Patients with Acute Myocardial Infarction during Primary Angioplasty

作　　者：王耀辉[1] 乔淑贞[1] 祁家祥 段新杰[1] 

机构地区：[1]平顶山市第一人民医院心内科,河南平顶山467000

出　　处：《中国现代医生》2011年第23期60-61,64,共3页China Modern Doctor

摘　　要：目的评估血栓抽吸联合经抽吸导管梗死相关动脉内注射替罗非班在急性ST段抬高心肌梗死急诊PCI治疗中的应用。方法 46例急诊PCI患者随机分为实验组(23例,血栓抽吸和经抽吸导管注药后行PCI)和对照组(23例,血栓抽吸后行PCI)。观察TIMI血流、肌钙蛋白I峰值、术后ST段下降率及左心室射血分数等。结果实验组TIMI血流、肌钙蛋白I峰值、术后ST段下降率及左心室射血分数与对照组比较均有统计学意义。结论血栓抽吸联合经抽吸导管应用替罗非班能改善急性ST段抬高心肌梗死患者心肌灌注及预后。Objective To evaluate the effects of thrombus aspiration plus intra-infarct-related artery administration of tirofiban in treatment of acute myocardial infarction （ AMI ） patients by primary pereutaneous coronary intervention （ PCI ） .Methods All 46 patients with primary AM1 who underwent primary PCI were randomized into two groups, experimental group （23 cases, were treated with thrombus aspiration plus intra-infarct-related artery administration of tlroflhan ） and control group （ 23 cases, were routinely treated by primary angioplasty after thrombus aspiration ） .The incidence of no reflow, peak of troponin I （ TnI ）, regression rate of ST segment and left ventricular ejection fraction （ LVEF ） were followed up after PCI during hospitalization. Results The target vessel forward flow of TIMI grade, peak of TnI, regression rate of ST segment and LVEF in experimental group showed the improvement in comparison with control group. Conclusion Thrombus aspiration plus intra-infarct-related artery bolus administration of tirofiban in patients with STEMI undergoing primary angioplasty may improve myocardium perfusion and result in a better clinical prognosis compared to primary angioplasty after thrombus aspiration.

关 键 词：心肌梗死 梗死相关动脉内注射 替罗非班 

分 类 号：R541[医药卫生—心血管疾病]