子宫内膜异位症患者腹腔液中IGF-Ⅰ和PAPP-A的测定及相关性研究  

IGF-Ⅰ and PAPP-A Changes in the Peritoneal Fluid and the Relationship in the Patients of Endometriosis

作　　者：金海红[1] 刘惠宁[2] 曾宝金[1] 

机构地区：[1]浙江省台州医院妇产科,浙江台州317000 [2]湖南长沙湘雅医院妇产科,湖南长沙410008

出　　处：《中国现代医生》2011年第23期110-112,共3页China Modern Doctor

摘　　要：目的检测子宫内膜异位症(EMs)患者和对照组腹腔液中IGF-Ⅰ和PAPP-A的水平变化及相关性,探讨其在子宫内膜异位症发病机制中的作用。方法采用酶联免疫吸附法(ELISA)检测39例内异症患者(EMs组)及25例非内异症患者(对照组)腹腔液中IGF-Ⅰ和PAPP-A水平。结果①EMs组中,IGF-Ⅰ和PAPP-A水平分别为(117.1±36.6)ng/L、(2.85±0.56)ng/mL,均高于对照组的(79.5±18.7)ng/L、(1.93±0.56)ng/mL(P<0.05);②Ⅲ～Ⅳ期患者腹腔液中IGF-Ⅰ水平为(126.5±39.1)ng/L高于Ⅰ～Ⅱ期患者的(107.3±32.0)ng/L(P>0.05),而Ⅲ～Ⅳ期患者腹腔液中PAPP-A水平为(3.15±0.50)ng/mL高于Ⅰ～Ⅱ期患者的(2.55±0.45)ng/mL(P<0.05),且PAPP-A水平与r-AFS评分呈正相关;③EMs患者腹腔液中PAPP-A和IGF-Ⅰ水平无显著相关性(P>0.05)。结论腹腔液中IGF-Ⅰ和PAPP-A的增高可能与内异症的发病有关;PAPP-A与疾病的严重程度有关。Objective To detect the concentration of IGF- I and PAPP-A in the peritoneal fluid of women with the endometriosis, so as to investigate the role of PAPP-A and＇IGF-I in the pathogenesis of endometriosis. Methods The study group included 39 samples of peritoneal fluid from patients with endometriosis, and control group included 25 samples of peritoneal fluid from patients without endometriosis. The peritoneal fluids were collected at the time of laparoscopic operation. Concentration of IGF- I and PAPP-A were determined by enzyme linked immunosorbent assay （ ELISA ）. Results （1） The peritoneal fluid concentrations of ICF- I and PAPP-A in study group were significantly higher than that of control group （ 117.1 ± 36.6 ）ng/L vs （ 79.5 ± 18.7 ） ng/L, （ 2.85 ± 0.56 ） ng/mL vs （ 1.93 ± 0.56 ） ng/mL （ P 〈 0.05 ） ; （2） PAPP-A levels of severe endometriosis were significantly higher than that of mild endometriosis （ 3.15 ± 0.50 ）ng/mL vs （ 2.55 ± 0.45 ）ng/mL （ P 〈 0.05 ）. Significant correlation was found between the stages of endometriosis and the levels of PAPP-A. （3） There was no significant correlation bewteen the PF levels of PAPP-A and IGF- I . Conclusion The increased peritoneal levels of IGF- I and PAPP-A may play an important role in the pathogenesis of endometriosis; There is significant correlation between the levels of PAPP-A and the stages of endometriosis.

关 键 词：子宫内膜异位症 腹腔液 PAPP-A IGF-Ⅰ 

分 类 号：R711.71[医药卫生—妇产科学]