星点设计-效应面法优选妇雅净泡腾片提取工艺  

Optimization of Fuyajing Effervescent Tablet Extraction Process by Central Composite Design-Response Surface Method

作　　者：刘雪梅[1] 王志萍[1] 韦慧鲜[2] 

机构地区：[1]广西中医学院药学院,南宁530001 [2]广西中医学院研究生院,南宁530001

出　　处：《中国实验方剂学杂志》2011年第16期37-40,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广西壮医院院级课题(P2007048);广西中医药管理局科技专项(GZKZ09-14)

摘　　要：目的:采用星点设计-效应面法优选妇雅净泡腾片的提取工艺。方法:以乙醇量、乙醇体积分数和提取时间为主要影响因素,以虎杖苷含量、蛇床子素含量和浸膏得率为评价指标,用星点设计-效应面法选择提取工艺的最佳条件。结果:最佳提取工艺为加入10倍量60%乙醇、提取2次、每次2 h。结论:星点设计-效应面法优选妇雅净泡腾片的提取工艺方法简便,预测性好。Objective： The extraction process of Fuyajing effervescent tablet was optimized by central composite design-response surface method.Method：The main influential factors on extraction process included the quantity of ethanol,the concentration of ethanol and extraction time.The extraction conditions were evaluated by the yield of extract and the total content of polydatin and osthole.The response surface methodology was used to optimize the conditions of extraction.Result：The optimum condition of extraction was extracted 2 times for two hours with ten times amount of 60% ethanol.Conclusion：It is simple,convenient and high predictive to optimize the extraction process of Fuyajing effervescent tablet by central composite design-response surface method.

关 键 词：妇雅净泡腾片 星点设计-效应面法 提取工艺 虎杖苷 蛇床子素 

分 类 号：R283.6[医药卫生—中药学]