蒲黄炭对血瘀大鼠血液流变性、凝血时间及舌象体征的影响  

Effects of Carbonized Typhae Pollen on Hemorheological Parameters,Clotting Time and Tongue Presentations in Rats with Blood-stasis

作　　者：李芳[1] 孔祥鹏[1] 陈佩东[1] 张丽[1] 丁安伟[1] 

机构地区：[1]南京中医药大学江苏省方剂研究重点实验室,南京210046

出　　处：《中国实验方剂学杂志》2011年第16期154-157,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局公益性行业科研专项(HY11076631)

摘　　要：目的:观察蒲黄炭对急性血瘀模型大鼠血液流变性、凝血时间及舌象体征的影响。方法:SD大鼠随机分为6组,分别为正常组,模型组,云南白药组,蒲黄炭高、中、低剂量(15,6,3 g.kg-1)组。除正常组外,其余组复制急性血瘀大鼠模型,并比较蒲黄炭对其血液流变性、凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、纤维蛋白原含量(FIB)及舌象体征的影响。结果:蒲黄炭高、中、低剂量组均能明显降低血瘀大鼠全血低切黏度、血沉、红细胞刚性指数。在凝血时间影响方面,蒲黄炭高、中剂量组均能明显延长TT,PT,缩短APTT,降低FIB的含量。蒲黄炭低剂量组能明显缩短PT,APTT。在舌象体征方面,蒲黄炭在所设剂量下对舌水肿、出血均有一定的治疗作用,高剂量效果最好,其次是中、低剂量。结论:蒲黄炭能够改善血瘀大鼠异常的血液流变学指标,缩短APTT,降低纤维蛋白原含量,改善舌象血瘀体征,而表现出一定的化瘀止血功效。蒲黄炭高、中剂量组使血瘀大鼠PT,TT延长,在一定程度上表现出剂量对止血的双向调节作用。Objective： To investigate the effects of carbonized Typhae Pollen on the hemorheological parameters,clotting time and tongue presentations in acute blood-stasis model of rat.Method： The SD rats were divided into control,model,Yunnan White Drug-power,carbo power of Typhae Pollen（high,middle and low dosage,15,6,3 g·kg-1 accordingly）.Except the control group,blood stasis model was established in the rest groups.The hemorheological parameters,the prothrombinase time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）,fibrinogen（FIB） and the signs of tongue presentations were detected in these groups.Result： Carbonized Typhae Pollen in high,middle and low dosage could decrease the viscosity of whole blood（ηb） at low shear rate,erythrocyte sedime natation rate（ESR） and rigidity of erythrocyte,which increased in model rats.Carbo of Typhae Pollen of high and middle dosage could lengthen TT,PT,shorten APTT and decrease FIB,while low dosage could shorten PT and APTT.Carbo of Typhae Pollen showed therapeutical effect in hydrops and bleeding of tongue and the high dosage showed the best effect.Conclusion： Carbonized Typhae Pollen showed the effect of invigorating blood and hemostasis by ameliorating the abnormal hemorheological parameters and the signs of tongue blood stasis.Carbonized Typhae Pollen in high and middle dosage could lengthen PT and TT,which showed the dosage has two-way regulating functions on hemostasis.

关 键 词：蒲黄炭 血液流变性 凝血 舌象体征 

分 类 号：R285.5[医药卫生—中药学]