加减“四四二合方”治疗原发性痛风性肾病  

Effect of Modfidy Sisi Erhefang on Gouty Nephropathy

作　　者：张汉新[1] 麻志恒[1] 施志琴[1] 黄美琴[1] 王恒[1] 王静[1] 

机构地区：[1]上海交通大学医学院附属新华医院崇明分院中医内科,上海202150

出　　处：《中国实验方剂学杂志》2011年第16期248-250,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：崇明县科委课题(CK2010-33)

摘　　要：目的:观察加减"四四二合方"治疗原发性痛风性肾病(湿热痰浊瘀血内阻型)的临床疗效。方法:104例原发性痛风性肾病(湿热痰浊、瘀血内阻型)的患者随机分为治疗组58例和对照组46例,两组一般治疗相同,治疗组另外予加减四四二合方,对照组给予别嘌呤醇。治疗8周后观察两组患者的症状,体征以尿酸(UA),肌酐(Cre),尿素(UN),β2-微球蛋白(β2-M),24 h尿蛋白的变化。结果:治疗组,对照组总有效率分别为84.5%,71.8%,两组比较有显著性差异(P<0.05),治疗前后各组内比较,两组的UA,CRE,UN,β2-MG,24 h尿蛋白均有所好转(P<0.05或P<0.01),治疗后组间比较,部分指标也有显著性差异(P<0.05或P<0.01),治疗组总体优于对照组。结论:加减"四四二合方"对原发性痛风性肾病有较好的临床疗效。Objective： To investigate the effect of modfidy Sisi Erhefang on gouty nephropathy.Method：One hundred and four patients with gouty nephropathy were randomized into two groups,58 patients in the treated group were treated with modfidy Sisi Erhefang,and 46 patients in the control group were treated with allopurinol,symptom,uric acid（UA）,creatinine（Cre）,urea nitrogen（UN）β2-microglobulin（β2-M） and 24 h urine protein of patiens in two groups were measured before and after treatment for 8 weeks.Result：Improvements of symptoms and decreasing of UA,Cre,UN,β2-MG and 24 h urine protein in the treated group was superior to those in the control group（P0.05 or P0.01）.Conclusion：Modfidy Sisi Erhefang present good effect in treating gouty nephropathy.

关 键 词：原发性痛风性肾病 加减四四二合方 中医药 

分 类 号：R287[医药卫生—中药学]