正丁酸钠对急性CO中毒家兔血液循环的影响  

Effect of sodium butyrate on blood circulation after acute carbon monoxide poisoning in rabbits

作　　者：王慧峰[1,2] 何先弟[1] 

机构地区：[1]蚌埠医学院第一附属医院ICU,安徽蚌埠233004 [2]河南大学第一附属医院ICU,河南开封475001

出　　处：《蚌埠医学院学报》2011年第8期799-801,共3页Journal of Bengbu Medical College

摘　　要：目的：观察正丁酸钠对急性CO中毒后家兔血液循环的影响,探讨其脑保护的可能作用机制。方法：取24只普通级健康家兔,随机分为正常对照组、急性CO中毒组（模型组）和急性CO中毒正丁酸钠预处理组（干预组）,每组8只。家兔腹腔注入高纯CO气体制备急性CO中毒模型。干预组在家兔造模前10 min经耳缘静脉注射500 mg/kg正丁酸钠。造模后第7天检测血液流变学及血小板聚集率指标。结果：模型组血液流变学及血小板聚集率各指标较对照组差异均有统计学意义（P〈0.01）,干预组血液流变学和血小板聚集率各指标均较模型组下降（P〈0.05~P〈0.01）,而干预组较对照组差异无统计学意义（P〉0.05）。结论：正丁酸钠可明显改善急性CO中毒引起的血液循环障碍,其作用机制极可能是通过抑制核因子-κB信号转导途径发挥抗炎效应,阻断炎症-凝血网络,从而改善血液循环而发挥脑保护作用。Objective：To observe the effect of sodium butyrate on blood circulation after acute carbon monoxide poisoning in rabbits,and explore the possible mechanism of brain protection.Methods：Twenty-four healthy rabbits were randomly divided into control group,acute CO poisoning group（model group）,and sodium butyrate pretreatment group（intervention group）,8 in each group.The high purity CO gas was injected intraperitoneally in rabbits to prepare the model of acute CO poisoning.Sodium butyrate was given by ear vein by 500 mg/kg to intervention group before preparing model ten minutes 7 days after modeled,hemorheology and platelet aggregation rate were tested.Results：After acute CO poisoning,all indicators of hemorheology and platelet aggregation of model group compared with control group significantly different（P〈0.01）,intervention group decreased compared with model group（P〈0.05-P〈0.01）,while there had no difference statistically between sodium butyrate pretreatment group and control group（P〉0.05）.Conclusions：Sodium butyrate can ameliorate blood circulation disorder significantly which caused by acute CO poisoning,its possible mechanism was through inhibition of nuclear factor-κB signal transduction pathway to play an anti-inflammatory effect,blocked the inflammation-coagulation network,thus played brain protection function through improvement of blood circulation.

关 键 词：一氧化碳中毒 正丁酸钠 血液流变学 血小板聚集率 

分 类 号：R595.1[医药卫生—内科学]