姜黄素对食饵性高脂血症小鼠血脂的影响及其抗氧化性作用  

Effect of Curcumin on Blood Lipids in Hyperlipidemic Mice and Its Antioxidant Effect

作　　者：杨奕樱[1] 陈继婷[1] 

机构地区：[1]贵阳中医学院,贵州贵阳550002

出　　处：《河南中医》2011年第8期861-862,共2页Henan Traditional Chinese Medicine

基　　金：贵阳中医学院青年基金(编号:中医科发[2006]312号)

摘　　要：目的:观察姜黄素对高脂血症小鼠总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白(HDL)和谷胱甘肽过氧化物酶(GSH-PX)含量的影响及其抗氧化性作用。方法:将60只清洁级雄性小鼠分为正常组10只、高脂血症模型组50只。饲养4周后,按每组10只分为:高脂血症模型组、阳性对照组,姜黄素低、中、高剂量组,给药3周后处死,取血,检测TC、TG、LDL-C、HDL、GSH-PX。结果:与正常对照组比较,姜黄素能降低TC、TG(P<0.01)、LDL-C含量(P<0.05),升高HDL、GSH-PX含量(P<0.05),有统计学意义。结论:姜黄素具有降低高脂饮食小鼠TC、TG、LDL含量,升高HDL、GSH-PX含量的作用。Objective： To observe the effects of curcumin on levels of total cholesterol（TC）,triglycerides（TG）,low-density lipoprotein cholesterol（LDL-C）,high density lipoprotein（HDL） and glutathione peroxidase（GSH-PX） of mice with hyperlipidemia and its antioxidant effect.Methods： 60 male mice of clean grade were divided into normal group（10）,hyperlipidemia model group（50）.After 4 weeks of feeding,hyperlipidemia model group were subdivided into 5 groups,10 in each group： hyperlipidemia model group,positive control group,low dose curcumin group,medium and high dose group,they were killed to test the content of blood TC,TG,LDL-C,HDL,GSH-PX three weeks after the administration.Results： Compared with normal control group,curcumin can reduce the levels of TC,TG（P0.01）,LDL-C（P0.05）,increase levels of HDL,GSH-PX（P0.05）,with a statistical significance.Conclusion： Curcumin can reduce the levels of TC,TG,LDL of mice with high-fat diet,and increase the levels of HDL,GSH-PX.

关 键 词：食饵性高脂血症 姜黄素 血脂 TC TG LDL-C HDL GSH-PX 小鼠 

分 类 号：R285.5[医药卫生—中药学]