调脂药物对动物与临床试验疗效的比较  

The efficacy of lipid lowering drugs on animals and clinical trials

作　　者：樊希承[1] 黄颖[1] 黄亦琦[1] 杨辉[1] 罗友华[1] 王梅兰[1] 

机构地区：[1]福建省厦门市医药研究所,361003

出　　处：《实用医技杂志》2011年第8期791-792,共2页Journal of Practical Medical Techniques

基　　金：福建省厦门市科技局资助项目(3502Z2001106)

摘　　要：目的对调脂药物动物实验和临床试验治疗结果进行对比和评价。方法动物实验建立高脂血症大鼠模型,将大鼠分为对照组、模型组(造模成功后,分为药物治疗组和自然恢复组),测各组血液生化指标并作比较。临床试验:选取高脂血症患者,排除糖尿病及其他心血管系统疾病等。服药前后测定多种血清生化指标与健康对照组进行比较。结果调脂药物对动物实验和临床试验均有很明显降血脂作用。临床试验结果显示差异有统计学意义(P<0.05),动物实验结果显示差异有统计学意义(P<0.01)。结论调脂药物对高脂血症大鼠模型和高脂血症患者均有临床疗效。Objective To compare and evaluate efficacy of the animal experiments and clinical trials of drug treatment.Methods Animal experiments： The high cholesterol rats model was established.All the rats were divided into 2 groups： control group and model group which was divided into treatment group and natural recovery group after modeling success.The blood biochemical parameters of each group were detected and compared.Clinical trials： the patients with high cholesterol and without diabetes and other cardiovascular disease were selected.The biochemical parameters of lipid of 38 cases were compared with those of control group before and after drug treatment.Results The treatment of animal experiments and clinical trials results indicated that the lipid lowering drug is effective.Clinical trials showed statistically significant differences（P0.05）,while animal experiments showed more significant difference（P0.01）.Animal experiments treatment showed the more desirable results.Conclusion Lipid-lowering drugs had better treatment effect on both the model rats and patients with hyperlipidemia.

关 键 词：降血脂药 动物实验 临床试验 对比研究 

分 类 号：R285[医药卫生—中药学]