冠心病与炎症因子IL-6、IL-8、IL-10、hs-CRP及TNF的相关性研究  

Study of the Relationship between Coronary Heart Disease and Inflammatory Factors:IL-6、IL-8、IL-10、hs-CRP、TNF

作　　者：刘虹 徐庆科[2] 夏伟 张纯全 王燕 

机构地区：[1]山东省青岛市立医疗集团东院心内科,266000 [2]青岛大学医学院附属医院东区心内科

出　　处：《实用心脑肺血管病杂志》2011年第9期1446-1447,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨冠心病与炎症标志物IL-6、IL-8、IL-10、hs-CRP、TNF的关系。方法测定176例冠心病患者及44例健康对照者血中IL-6、IL-8、IL-10、hs-CRP、TNF水平,并分析其与患者病情及冠脉病变严重程度的关系。结果冠心病组IL-6、IL-8、IL-10、hs-CRP、TNF水平较对照组明显增高。在冠心病组,随病情严重程度增加以上炎症指标逐渐增高(AM I>UAP>SAP),冠脉病变的严重程度越高炎症指标水平也越高(三支病变组>二支病变组>单只病变组)。结论炎症反应与冠心病的发生、发展有关,监测血中IL-6、IL-8、IL-10、hs-CRP、TNF等炎症标志物的水平能够预测冠心病病情及病变严重程度。Objective To study the relationship between IL-6、IL-8、IL-10、hs-CRP、TNF and CHD.Methods Serum levels of IL-6、IL-8、IL-10、hs-CRP and TNF were measured in 176 patients with CHD and 44 normal controls.Results Serum levels of IL-6、IL-8、IL-10、hs-CRP and TNF in patients with CHD were significantly higher than the normal controls;the severer the disease,the higher the levels（acute myocardial infarctionunstable angina pectorisstable angina pectoris）.Serum levels of IL-6、IL-8、IL-10、hs-CRP and TNF also increased with the increasing extent of the number of diseased coronary vessels（the 3-vessel-disease grouPthe 2-vessel-disease grouPthe 1-vessel-disease group）.Conclusion Inflammatory reaction was closely associated with CHD.Measuring the levels of IL-6、IL-8、IL-10、hs-CRP、TNF are important in the diagnosis,treatment and prognosis of CHD.

关 键 词：冠心病 白细胞介素 高敏C反应蛋白 肿瘤坏死标志物 

分 类 号：R541.4[医药卫生—心血管疾病]