巴戟天提取物对大鼠类风湿性关节炎作用的观察  

Observation of the effect of Morinda offcinalis How on rat rheumatoid arthritis

作　　者：陈岚[1] 陈翠[2] 高毅[1] 任海祥[2] 

机构地区：[1]南京军区杭州疗养院海勤疗养区,浙江杭州310002 [2]南京军区南京总医院制剂科,江苏南京210002

出　　处：《东南国防医药》2011年第4期305-307,共3页Military Medical Journal of Southeast China

摘　　要：目的研究巴戟天提取物对大鼠类风湿性关节炎的抗炎作用。方法采用完全Freund's佐剂诱导大鼠类风湿性关节炎和0.6%冰醋酸致小鼠疼痛扭体模型,分别以大鼠足踝关节周径、炎症介质PGE2含量,小鼠扭体次数为指标,观察巴戟天提取物对实验性类风湿性关节炎的作用。结果 巴戟天提取物中剂量、高剂量对完全Freund's佐剂所致的大鼠足肿胀有明显抑制作用,能降低PGE2的含量(P<0.05,P<0.01);减少冰醋酸所致的小鼠扭体次数(P<0.01)。结论巴戟天提取物具有一定的抗类风湿性关节炎作用,其抗炎镇痛作用和降低炎症介质PGE2含量密切相关。Objective To study effects of extract from Morinda offcinalis How on the rheumatoid arthritis.Methods AA in rats was induced by Freunds complete adjuvant.Mice retortion pain model is induced by 0.6% glacial acetic acid.The diameter of ankle joint,mediators of inflammation PGE2 and the writhing frequency are effect index.Researched effects of extract from Morinda offcinalis How on the rheumatoid arthritis.Results The extract from Morinda offcinalis How medium dose and high dose both significant inhibited the ankle swelling of AA in rats and decreased the PGE2（P0.05,P0.01）,they also reduced the writhing frequency of mice induced by glacial acetic acid（P0.01）.Conclusion Morinda offcinalis How extracts has therapeutic effects on rheumatoid arthritis,which mechanism is related to its effects on reducing the mediators of inflammation PGE2,anti-inflammatory and analgesia.

关 键 词：类风湿性关节炎 巴戟天 冰醋酸 抗炎 镇痛 

分 类 号：R593.22[医药卫生—内科学]