罗格列酮对雌性大鼠骨代谢的影响  

Effects of rosiglitazone on the bone metabolism in female rats

作　　者：侯艳丽[1] 季虹[1] 王东[1] 李新华[1] 王庆美[1] 黄丽芳[1] 林鲁霞[1] 刘延杰[1] 臧学章[1] 荣海钦[1] 

机构地区：[1]山东省内分泌与代谢病研究所,山东省医学科学院,济南250062

出　　处：《中国骨质疏松杂志》2011年第8期665-668,共4页Chinese Journal of Osteoporosis

基　　金：山东省自然科学基金资助项目(基金编号ZR2009CL028);山东省医药卫生科技发展计划(基金编号2009HW082)

摘　　要：目的观察马来酸罗格列酮对雌性大鼠骨代谢的影响。方法 3月龄雌性Wistar大鼠40只随机分为4组,正常对照组(NC组)、低剂量(3mg.kg-1.d-1)罗格列酮组(Ros-1组)、中剂量(10mg.kg-1.d-1)罗格列酮组(Ros-2组)和高剂量(30 mg.kg-1.d-1)罗格列酮组(Ros-3组)。每日定时按照每公斤体重6ml灌胃,NC组给予0.5%羧甲基纤维素钠溶液灌胃作为对照,干预12周。处死后,测定右侧股骨骨密度、血清骨代谢标记物和相关激素及细胞因子水平。结果 Ros-3组的股骨骨密度较其他三组显著降低,反映骨形成的血清骨钙素水平在Ros-2及Ros-3组显著降低,而其他骨代谢标记物无显著变化。各组的雌二醇、睾酮、瘦素水平无差异。Ros-3组IGF-1水平降低。各组炎症因子的水平无有意义的变化。结论较大剂量的罗格列酮能减少正常雌性大鼠的骨形成,降低骨密度,对循环中雌二醇、睾酮及多数细胞因子无显著性影响。Objective To investigate the effects of rosiglitazone on the bone metabolism in female rats. Methods Forty 3-month-old female Wistar rats were randomly distributed into 4 groups, and were treated with rosiglitazone maleate at doses of 3, 10, and 30rag kg-1 ·d-1（Ros-1, Ros-2, and Ros-3）, or 0.5% carboxymethycellulose （NC） by gavage （6ml kg-1· d-I） for 12 weeks. Bone mineral density （BMD） of the right femur, serum bone metabolic markers, and related hormones and eytokines were measured after the rats were killed. Results BMD of the femur in group Ros-3 decreasad significantly compared to that in 3 other groups. The serum levels of osteocalcin decreased significantly in groups Ros-2 and Ros-3, but no change occurred in other bone metabolic markers. There was no difference in the levels of estradiol, testosterone, and leptin among the groups. The serum level of IGF-1 decreased in group Ros-3. No significant change occurred in the inflammatory factors among the groups. Conclusion Rosiglitazone at a higher dose decreases bone formation and BMD in the normal female rats. Rosiglitazone has no influence in serum levels of estradiol, testosterone, and most cytokines.

关 键 词：罗格列酮 骨钙素 骨密度 雌二醇 

分 类 号：R587.1[医药卫生—内分泌]