丹参(冻干粉针)结合唑来膦酸治疗恶性肿瘤骨转移临床研究  

Salvia Miltiorrhiza Lyophilization with Zoledronic Acid Therapy for Cancer Bone Pain Clinical Research

作　　者：黄智芬[1] 杨泽江[2] 刘俊波 黄常江 邓朝明[2] 

机构地区：[1]广西医科大学附属肿瘤医院,广西南宁530021 [2]灵山县人民医院,广西灵山535400 [3]贵港市中医院,广西贵港537100

出　　处：《中医学报》2011年第7期772-774,共3页Acta Chinese Medicine

摘　　要：目的:观察丹参(冻干粉针)结合唑来膦酸治疗恶性肿瘤骨转移对患者生活质量的影响。方法:将60例患者随机平均分为两组,治疗组采用丹参(冻干粉针)结合唑来膦酸治疗,对照组单用唑来膦酸治疗。结果:两组生存质量量表EORTCQLQ-SF-36调查问卷评分比较,生活质量治疗组优于对照组(P<0.05);而认知功能、社会功能比较,差异无统计学意义(P>0.05);治疗组症状较治疗前有显著改善(P<0.05);对照组治疗后与治疗前比较,差异无统计学意义(P>0.05),治疗组优于对照组。不良反应比较,治疗组低于对照组(P<0.05)。结论:丹参(冻干粉针)结合唑来膦酸治疗恶性肿瘤骨转移疼痛,能改善临床症状,减少不良反应,提高生活质量。Objective：To observe the the influence of salvia miltiorrhiza combined with Thiazole to the quality of life of the patients of cancer pain on bone metastases.Methods：60 cases were randomly divided into two groups,the average by salvia miltiorrhiza in treatment group（freeze-dried paclobutrazol to phosphonate combined treatment group paclobutrazol to phosphonate therapy alone.Observe two groups before and after treatment EORTCQLQ-SF living quality scale-36 questionnaire score and clinical symptom scores,adverse reactions.Results：Two groups of survival quality scale EORTCQLQ-SF-36 questionnaire score comparison,quality of life,the treatment group was better than control group（P0.05）.And cognitive function,social function difference was statistically significant（P0.05）.The treatment group therapy pain after,fatigue,loss of appetite,sleep got better than before treatment improed significantly（P0.05）.After treatment before treatment group is improved,but differences symptoms was not statistically significant（P0.05）,the treatment group than in control group.Adverse reaction compare,the treatment group lower than those of the control group（P0.05）.Conclusion：salvia miltiorrhiza（freeze-dried） combined with thiazole to phosphonate in treating malignant tumor bone pain can improve clinical symptoms and reduce adverse reactions,improve life quality and prolong surial.

关 键 词：恶性肿瘤 骨转移 丹参 唑来膦酸 生活质量 

分 类 号：R273.337[医药卫生—中西医结合]