川崎病患儿急性期血浆N端脑钠肽前体水平测定的临床意义  

作　　者：笪小虎 徐天祥[1] 

机构地区：[1]江苏省句容市人民医院,212400

出　　处：《首都医药》2011年第16期31-33,共3页Capital Medicine

摘　　要：目的通过检测川崎病(kawasaki disease,KD)患儿血浆N端脑钠肽前体(N-terminalpro-brain natriuretie peptide,NT-proBNP)水平,探讨NT-proBNP在川崎病早期诊断中的临床意义。方法将收集的58例KD患儿分为两组,其中典型KD组45例,不完全KD组13例,另选择18例年龄匹配的发热患儿为对照组。采用酶联免疫法分别测定KD患儿急性期、恢复期,以及对照组血浆NT-proBNP水平。结果 KD组(包括典型KD组和不完全KD组)急性期血浆NT-proBNP水平显著高于对照组(P均<0.01);典型KD组和不完全KD组急性期血浆NT-proBNP水平无统计学差异(P>0.05)。KD患儿恢复期血浆NT-proBNP水平较急性期显著下降(P<0.05)。冠脉损伤组急性期血浆NT-proBNP水平显著高于无冠脉损伤组(P<0.05)。结论 KD(包括不典型KD)患儿急性期血浆NT-proBNP水平显著升高,尤其当存在冠状动脉损伤时升高更明显。检测血浆NT-proBNP水平对KD的诊断,尤其是不典型KD的诊断有一定的参考价值,血浆NT-proBNP水平异常升高对预测冠脉损伤的发生有一定的意义。Ojective To explore the value of NT-proBNP in the diagnosis of KD by detecting the plasma level of NT-proBNP in children with KD.Methods Fifty-eight patients with KD were enrolled and divided into two groups：typical KD group（n=45） and in-complete KD group（n=13）.Eighteen agematched febrile patients were used as controls.Blood sample was obtained to detect plasma NT-proBNP concentrations in the acute and convalescent phases of KD and the control patients using enzyme immunoassay.Results Levels of the plasma NT-proBNP in both typical KD group and in-complete KD group in the acute phase were significantly higher than that of the control group（P 0.01）.There was no significantly difference in Level of the plasma NT-proBNP in the acute phase in typical KD group and in-complete KD group（P 0.05）.The plasma NT-proBNP concentration in the convalescent phase of KD decreased significantly compared with the acute phase（P 0.01）.The level of the plasma NT-proBNP in the acute phase was significantly higher in KD with coronary artery lesions（CAL） than in KD without CAL（P 0.05）.Conclusion The level of plasma NT-proBNP was significantly elevated in the acute phase of KD patients including in-complete KD,especially in KD patients with CAL.It might be one of the useful biological markers of KD and associated with coronary artery lesions.

关 键 词：川崎病 N端脑钠肽前体 诊断 检测 

分 类 号：R75[医药卫生—皮肤病学与性病学]