高迁移率族蛋白B1在慢性乙型肝炎患者肝组织中的表达及意义  

The expression and significance of HMGB1 in chronic hepatitis B

作　　者：牛春燕[1] 郑建云[2] 李雷[1] 高保华[1] 刘冰[2] 罗建梅[3] 

机构地区：[1]西安医学院附属医院消化内科,西安710077 [2]西安医学院附属医院病理科,西安710077 [3]西安医学院附属医院超声医学科,西安710077

出　　处：《临床肝胆病杂志》2011年第8期807-809,共3页Journal of Clinical Hepatology

摘　　要：目的了解高迁移率族蛋白B1(HMGB1)在慢性乙型肝炎(CHB)患者肝组织中的表达及其与肝组织损伤程度的关系。方法经血清学证实为慢性乙型肝炎患者46例。对穿刺的肝组织采用常规HE染色、Masson三色特染及Gordon-Sweet银染法观察肝组织炎症与纤维化程度,用免疫组化方法判断HMGB1在肝组织中的表达。结果正常肝组织HMGB1不表达或在细胞核内微弱表达,HMGB1随肝脏炎症及纤维化加重而表达逐渐增强(P<0.005)。结论 HMGB1与肝组织的炎症及纤维化程度密切相关,可作为慢性乙型肝炎患者炎症及纤维化发展以及治疗随访、预后判断的敏感指标。Objective To investigate the expression of high mobility group box 1 protein （ HMGB1 ） in different liver tissue and its relation-ship with liver injury. Methods 46 liver specimens of chronic hepatitis B （CHB） patients were diagnosed by serology test. The hepatic in- flammation and fibrosis degree were tested by HE, Masson and Gordon - Sweet staining. Immunohistochemical method was used to detect the expression of HMGB1. Results HMGB1 didn＇ t or weakly expressed in normal liver tissue, while strongly expressed along with aggravative hepatic inflammation and fibrosis（ P 〈 0. 005 ）. Conclusion HMGB1 expression is positively correlated with hepatic inflammation and fibrosis, which is the sensitive indicator of treatment and prognosis.

关 键 词：肝炎 乙型 慢性 HMGB1蛋白 

分 类 号：R512.62[医药卫生—内科学]