洛土辛对大鼠及狗血流动力学的影响  

Effect of Lotusine on Haemodynamics in Rat and Canine

作　　者：王嘉陵[1] 赵志方[1] 张帆[1] 江明性[1] 

机构地区：[1]同济医科大学药理教研室,武汉430030

出　　处：《中草药》1999年第11期838-840,共3页Chinese Traditional and Herbal Drugs

基　　金：武汉市科委自然科学基金

摘　　要：采用左心室及血管插管法，研究了洛土辛（Ｌｏｔ）对大鼠及狗血流动力学的影响。 Ｌｏｔ ２．５，５，１０ ｍｇ／ｋｇ，ｉｖ可剂量依赖性地增加麻醉大鼠的左心室压（ＬＶＰ）、左室压力变化最大速率（±ｄｐ／ｄｔｍａｘ）、动脉收缩压（ＳＡＰ），降低左室舒张末期压（ＬＶＥＤＰ），但对心率（ＨＲ）和动脉舒张压（ＤＡＰ）却无明显的影响。麻醉大鼠 Ｌｏｔ ５ ｍｇ／ｋｇ、麻醉狗 Ｌｏｔ ３ ｍｇ／ｋｇ，ｉｖ可获相似结果，其对狗血流动力学影响的起效时间较快且作用持续较长。在毁脊髓大鼠，Ｌｏｔ ５ ｍｇ／ｋｇ，ｉｖ不仅显著地增加 ＬＶＰ，±ａｐ／ｄｔｍａｘ，ＳＡＰ，明显增加ＤＡＰ和ＨＲ。提示Ｌｏｔ对血流动力学影响的特性与ＰＤＥ Ⅲ抑制剂相似。Lotusine (Lot ), a pure alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn, has been demonstrated to possess the properties of phosphodiesterase Ⅲ inhibitors in isolated myocardium and blood vessels. In this paper, the effects of Lot on haemodynamics were studied in rat and canine, Lot 2.5, 5, 10 mg/kg, iv could obviously increase left ventricular pressure (LVP), systolic or diastolic maximum rate of pressure change (±dp/dt), left ventricular end diastolic pressure (LVEDP) and systolic artery blood pressure (SAP) in dose dependent manners. But there is no significant influence on diastolic artery blood pressure (DAP) and heart rate (HR ). In anesthetized rat, with Lot 5 mg/kg, iv and anesthetized canine with Lot 3 mg/kg, iv, results similar to the above could be obtained. Moreover, it was found that the effect of Lot on anesthetized canine appeared earlier and was more persistent than that on anesthetized rat. In pithed rat, Lot 5 mg/kg, iv enhanced not only LVP, ±dp/dt, SAP, but also DAP and HR. The results suggested that the properties of the effect of Lot on haemodynamics are similar to that of phosphodiesterase Ⅲ inhibitors.

关 键 词：洛土辛 血流动力学 磷酸二酯酶 抑制剂 

分 类 号：R285.5[医药卫生—中药学]