依达拉奉联合依帕司他治疗糖尿病周围神经病变的疗效观察  

Effective observation of epalrestat and edaravone in treating diabetic peripheral neuropathy

作　　者：刘湘茹[1] 刘碧云[1] 杨斌[1] 胡德龙[1] 房洁新[1] 

机构地区：[1]佛山市顺德区第一人民医院,广东佛山528300

出　　处：《现代医药卫生》2011年第16期2419-2421,共3页Journal of Modern Medicine & Health

摘　　要：目的:探讨依达拉奉联合依帕司他治疗糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)的临床疗效。方法:将87例糖尿病周围神经病变患者随机分为两组,治疗组采用依达拉奉联合依帕司他治疗,对照组采用甲钴胺治疗。观察临床疗效及肌电图变化。结果:治疗组总有效率明显高于对照组(P<0.05),治疗组感觉神经传导速度及运动神经传导速度均明显高于对照组(P<0.05)。结论:依达拉奉联合依帕司他治疗糖尿病周围神经病变效果优于甲钴胺。Objective：To investigate the clinical effect of epalrestat combined with edaravone in treating diabetic peripheral neuropathy.Methods：87 patients with diabetic peripheral neuropathy were randomly divided into two groups.The treatment group（n=45） was treated with epalrestat combined with edaravone.The control group（n=42） was treated with mecobalamine.The clinical effects and electromyography changes were observed in the two groups.Results：The total effective rate in the treatment group was significantly higher than that in the control group（P0.05）.After treatment,the sensory nerves conduction velocity（SNCV） and the motor nerve conduction velocity（MNCV） in the treatment group were obviously higher than those in the control group（P0.05）.Conclusion：Epalrestat combined with edaravone is superior to mecobalamine in treating diabetic peripheral neuropathy.

关 键 词：糖尿病 周围神经病变 依帕司他 依达拉奉 

分 类 号：R5[医药卫生—内科学]