c-fos在低氧适应高原鼢鼠(Myospalax baileyi)延髓中表达的免疫组织化学研究  

Expression of Fos in medulla of Myospalax baileyi:Adaptation to Hypoxia

作　　者：马永贵[1] 贺玉姣[1] 谢惠春[1] 

机构地区：[1]青海师范大学青藏高原环境与资源教育部重点实验室,青海西宁810008

出　　处：《青海师范大学学报（自然科学版）》2011年第2期32-36,共5页Journal of Qinghai Normal University(Natural Science Edition)

摘　　要：本研究以高原鼢鼠为材料,运用组织学和免疫组织化学研究方法,对营地下生活的高原鼢鼠经过低氧处理后延髓中Fos蛋白的表达情况进行研究.结果表明,经过低氧适应后,高原鼢鼠延髓中Fos蛋白表达的量随低氧浓度的降低而升高,较常氧组,低氧浓度14.1%7天组、低氧浓度10.5%7天组、低氧浓度6.5%1天组Fos蛋白的表达量分别升高了3.67倍、7.76倍和33.38倍.同时在一定的低氧浓度中,Fos蛋白的表达量随低氧时程的延长而降低.高原鼢鼠在低氧浓度14.1%以下,7天低氧适应延髓中Fos蛋白表达量低于4天适应的表达量(P>0.05);同时在低氧浓度10.5%下,7天低氧适应延髓中Fos蛋白表达量极显著低于4天适应的表达量(P<0.01).由此可见,高原鼢鼠能够适应低氧环境,在低氧刺激下,神经系统反应敏感,能够主导机体各系统的低氧反应.Myospalax baileyi lives underground all its life,where is relatively short of oxygen.In the present experiment,we studied Fos expression content of the medulla using histological and immunohistochemistry method.The results are as follows： Fos expression content of intermittent hypoxic rats were increased significantly as compared with normoxic control rats and presented linear changes.This result suggests that Myospalax cansus is adapted to hypoxic habitats and has stronger ability of hypoxic adaptation.And its nervous system is susceptible of hypoxia,which can lead the hypoxic reflection of all system in Myospalax cansus.

关 键 词：高原鼢鼠 C-FOS FOS 免疫组织化学 

分 类 号：Q494[生物学—生理学]