首乌藤黄酮的体内抗氧化作用研究  

Study on antioxidation effect in vivo of flavonoids from Caulis Polygoni Multiflori

作　　者：戴成国[1] 王纪平 肖扬[1] 牛付阁[1] 段玉峰[1] 

机构地区：[1]陕西师范大学食品工程与营养科学学院,陕西西安710062 [2]国药集团西北医药有限公司,陕西西安710001

出　　处：《陕西师范大学学报（自然科学版）》2011年第4期75-78,共4页Journal of Shaanxi Normal University：Natural Science Edition

基　　金：陕西省自然科学基金资助项目(2006D18)

摘　　要：为研究首乌藤黄酮(flavonoids fromCaulis Polygoni Multiflori,简称FCPM)的体内抗氧化作用,将ICR小鼠自由分成四组,分别灌喂高、中、低剂量FCPM和生理盐水,30 d后眼眶采血及组织取样,用试剂盒测定小鼠血清、肝脏、脑组织中MDA含量、SOD和GSH-PX酶活性及血清、肝脏中CAT酶活性.结果表明,FCPM可显著降低血清及组织MDA含量,提高小鼠的血清及组织的SOD、GSH-PX和CAT活力,表明FCPM具有显著的体内抗氧化活性.To study the antioxidation effect in vivo of flavonoids from Caulis Polygoni Multiflori（FCPM）,ICR mices were randomly divided into 4 group（stomach irritation with high/middle/low FCPM and salineonly）,contents malondialdehyde（MDA）,enzyme activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-PX） in the serum,liver/brain and enzyme activities of Catalase（CAT） in the serum,liver of ICR mice were measured by reagent box.The results showed that FCPM can significantly increase the activity of SOD/GSH-PX in the serum,liver/brain and increase the activity of CAT in the serum/liver,decrease the contents of MDA in the serum and the organs.FCPM can improve antioxidation ability in vivo and balance the state of antioxidation/oxidation.

关 键 词：首乌藤 黄酮 体内抗氧化 动物实验 

分 类 号：R282.71[医药卫生—中药学] R285.5[医药卫生—中医学]