有氧运动与山楂籽油干预对高脂饮食大鼠脂代谢、抗氧化能力及内皮细胞功能的影响  

Intervention effects of aerobic exercise and hawthorn seed oil on lipid metabolism、anti-oxidative capacity、endothelial function of SD rats fed with high fat diet

作　　者：范学辉[1] 张清安[2] 胡柏平[1] 宋伟[1] 

机构地区：[1]陕西师范大学体育学院,陕西西安710062 [2]陕西师范大学食品工程与营养科学学院,陕西西安710062

出　　处：《陕西师范大学学报（自然科学版）》2011年第4期103-108,共6页Journal of Shaanxi Normal University：Natural Science Edition

基　　金：教育部运动人体科学教学团队建设项目(2010-12);教育部高校博士点专项科研基金资助项目(20050718011);中央高校基本科研业务费专项资助项目(GK201002014)

摘　　要：在给SD(Sprague Dawley)大鼠喂饲高脂饮食的同时,进行有氧运动锻炼或/和补充山楂籽油,实验结束测定大鼠血清总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白(high-density lipoprotein-cholesterol,HDL-C)、一氧化氮(nitric oxide,NO)及内皮素(endothelin,ET)、血浆卵磷脂胆固醇酰基转移酶(lecithin cholesterol acyltransferase,LCAT)、超氧化物歧化酶(Superoxide dismutase,SOD)活性及丙二醛(malondialdehyde,MDA)的变化.结果表明:与高脂模型组相比,有氧运动锻炼或/和补充山楂籽油组大鼠血清及血浆TC、TG、HDL-C、LCAT、SOD、MDA、NO、ET分别有显著性(P<0.05)或极显著性差异(P<0.01).山楂籽油及有氧耐力运动均可提高LCAT活性及机体抗氧化能力,调节ET和NO的平衡来改善血管内皮功能障碍,改善血脂代谢紊乱;且二者恰当结合,有助于发挥协同作用优势,提高预防动脉粥样硬化作用.While the SD rats were fed with high fat diet,the aerobic exercise training was conducted and hawthorn seed oil was supplemented for three weeks.The serum triglyceride（TG）,total cholesterol（TC）,high-density lipoprotein-cholesterol（HDL-C）,lecithin cholesterol acyltransferase（LCAT）,superoxide dismutase（SOD）,malondialdehyde（MDA）,nitricoxide（NO）,and the endothelin（ET） were determined at the end of the experiment.Conclusions：In Hyperlipidemia exercise group（HE）,Hyperlipidemia Hawthorn seed oil group（HH） and Hyperlipidemia Hawthorn seed oil exercise group（HHE）,the levels of TC、TG、HDL-C、LCAT、 SOD、 MDA 、NO、 ET in blood had significant changes or relatively significant changes（P0.05 or P0.01）,compared with Hyper lipidemia model group.Hawthorn seed oil and aerobic training both improve activity of LCAT and antioxidant effects,improve endothelial dysfunction regulating the balance between ET and NO,and better blood lipid metabolism disorder;the appropriate combination of both will help to make use of advantage in synergy and enhance the role of prevention of atherosclerosis.

关 键 词：有氧运动 楂籽油 血脂代谢 抗氧化酶 一氧化氮 内皮素 卵磷脂胆固醇酰基转移酶 

分 类 号：G804.7[文化科学—运动人体科学]