连翘对水貂呕吐模型止呕作用的研究  

Anti-emetic effects of Lianqiao(连翘) on a emetic model in mink

作　　者：马洪新[1] 卢燕[1] 林艳艳[1] 聂克[1] 

机构地区：[1]山东中医药大学,济南250355

出　　处：《中药药理与临床》2011年第3期74-76,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：山东省科技攻关计划项目(编号:2007GG2NS02071)

摘　　要：目的:利用水貂呕吐模型观察连翘的止呕作用。方法:(1)将水貂随机分为6组,第1组灌胃蒸馏水15ml/kg,第2组腹腔注射昂丹司琼2mg/kg,第3、4、5、6组分别ig连翘水煎液3g/kg、10g/kg、15g/kg和连翘醇提液10g/kg;第2组给药后0.5h,其余五组给药后1h,分别ip顺铂7.5mg/kg。记录各组动物在给予顺铂后6h内的呕吐潜伏期、干呕和呕吐次数。(2)将水貂随机分为3组,第1组ig蒸馏水15ml/kg,第2组ip甲氧氯普胺4mg/kg,第3组ig连翘水煎液10g/kg。第2组给药后0.5h,其余2组给药后1h,分别皮下注射阿朴吗啡1.0mg/kg。记录各组动物在给予阿朴吗啡后6h内的呕吐潜伏期、干呕和呕吐次数。(3)将水貂随机分为3组,第1组ig蒸馏水15ml/kg,第2组ip甲氧氯普胺4mg/kg,第3组ig连翘水煎液10g/kg。各组给药后0.5hi,.g.硫酸铜40mg/kg,记录各组动物在给予硫酸铜后6h内的呕吐潜伏期、干呕和呕吐次数。结果:连翘能够延长顺铂、阿朴吗啡、硫酸铜所致的水貂呕吐潜伏期,减少干呕次数。结论:连翘对上述三种经典催吐剂导致的水貂呕吐模型均具有止呕作用。Objective：To investigate the anti-emetic effects of lianqiao（LQ） on a nausea model of mink.Method ：①：Divided the minks into six groups randomly,giving distilled water（group one,ig,15ml/kg）,Ondansetron（group two,ip,2mg/kg）,the decoction of LQ（ig,3g/kg,10g/kg,15g/kg） and the ethanol extraction of LQ（ig,10g/kg） respectively,and giving cisplatin（ip,7.5mg/kg） 1h later to each group except group two which only need waiting 0.5h.②：Divided the minks into three groups randomly,giving distilled water（group one,ig,15ml/kg）,metoclopramide（group two,ip,4mg/kg）,and LQ Decoction（ig,10g/kg） respectively,and giving apomorphine（sc,1.0 mg/kg） 1h later to each group except group two which only need waiting 0.5h.③：Divided the minks into three groups randomly,giving distilled water（ig,15ml/kg）,metoclopramide（ip,4mg/kg）,and the decoction of LQ（ig,10g/kg） respectively,and giving copper sulfate（ig,40 mg/kg） 0.5h later to each group.Observing and recording the potential period of vomiting,the number of retching and vomiting in the subsequently six hours in each case.Results：LQ can prolong the potential period of the vomitting and decrease the number of retches induced by the cisplatin,apomorphine,and the copper sulfate.Conclusion：LQ has anti-emetic effect on the nausea model of mink induced by the classic emetics mentioned above,and the mechanism of action might be related with both center and periphery nervous system routes.

关 键 词：连翘 止呕 水貂 

分 类 号：R285[医药卫生—中药学]