方剂组学:一种基于方剂提取物质控的中医药转化医学研究策略  

Formulomics:a strategy for translational medicine research of traditional Chinese medicine based on formula extraction quality control

作　　者：孙学刚[1] 吕志平[1] 

机构地区：[1]南方医科大学中医药学院,广州510515

出　　处：《中药药理与临床》2011年第3期120-122,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金(30973699)

摘　　要：方剂组学以中医方剂作为研究内容,以提取物质量控制为前提,以临床疗效为基础而建立的提取工艺规范、物质基础固定、治疗效果确切、作用靶点明确、调控机制清楚的新型中药复方研究模式,是将中医方剂转化为临床药物的转化医学策略。该研究模式注重质量控制和物质基础研究、是一种双向反馈研究模式和开放性研究平台,将有助于推动复方药理研究的规范化和国际化。Formulomics is a new strategy to research formula of traditional Chinese medicine（TCM） based on strict extract quality control and established clinical efficacy.Standard extraction process,fixed material basis,exact treatment effects,clearly target and regulatory mechanism are necessary conditions for formulomics research.The research model focuses on quality control and material basis analysis.Formulomics is a two-way feedback research mode,an open platform and a translational medicine strategy to translate formula of TCM to clinical drugs.It would promote the standardization and internationalization of TCM formula resarch.

关 键 词：方剂组学 提取物 质量控制 转化医学 

分 类 号：R289[医药卫生—方剂学]