铅作业女工子女神经行为和神经生化改变的配对研究  

Paired study on the neurobehavioral and neurochemical changes in children of women workers exposed tolead

作　　者：何云[1] 许发茂[1] 杨杏芬[1] 邓丽霞[1] 王充[1] 周炯亮[1] 

机构地区：[1]中山医科大学公共卫生学院劳动卫生与职业病教研室,广州市510089

出　　处：《中国职业医学》1999年第6期8-10,共3页China Occupational Medicine

基　　金：中华医学基金会行为医学中心资助

摘　　要：目的　通过观察铅作业女工子女（６ ～１０ 岁） 及１∶１ 对照组血铅、发铅、神经行为及生化的差异，了解铅对神经行为的影响及其生物学基础。方法　采用ＷＨＯ 推荐的神经行为测试组合中适宜儿童的四项测定神经行为功能，采用高效液相色谱法－ 电化学法联检测定尿中高香草酸（ＨＶＡ） 和香草扁桃酸（ＶＡＭ） 的浓度。所得资料用ＳＰＳＳ 软件进行配对ｔ 检验。结果　接触组尿液中ＨＶＡ 和ＶＭＡ 减少（ Ｐ＜０－００１） ，数字广度及最快反应时间得分减少（ Ｐ＜ ０－００１） 。结论　铅对女工子代的ＨＶＡ、ＶＭＡ、数字广度及最快反应时等神经行为生化指标有影响。Objective To study the effects oflead on neurobehavioral and biochemical alterations among the children of womenlead workers. Methods The neurobehavioralfunctions weretested byfouritems of neurobehavioral coretest battery supposedto be suitedto children .HVAand VMAin urine were determined by high- performanceliq uid chromatography (HPLC) - electric chemistry (EC) method . Data collected were analyzed by SPSSsoftware in mi crocomputerfor paired design ttest. Results Amongthese children of womenlead workers,levelsof HVAand VMA in urine appeared to be decreased ,scores of Digit Span and Minimum Reaction Time also decreased obviously ( P< 0-001) .Conclusion Lead mighthave some effects on urinary HVA,VMAand on DigitSpan Minimum Reaction Time in children dueto lead exposure oftheir mothers.

关 键 词：铅 神经行为功能 神经化学 配对分析 作业女工 

分 类 号：R135.11[医药卫生—劳动卫生]