益气滋肾冲剂对IgA肾病小鼠肾小球超微结构的影响  

Effect of Yiqi Zishen Granule on Ultrastructure of Glomeruli of IgA Nephropathy in Mice

作　　者：聂莉芳[1] 余仁欢[1] 林秀彬[1] 方芳[1] 王国栋[1] 魏晓超[2] 

机构地区：[1]中国中医研究院西苑医院肾病科,北京100091 [2]北京医科大学基础医学院

出　　处：《中国中西医结合杂志》1999年第12期737-739,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家中医药管理局留学回国人员择优课题

摘　　要：目的:探讨益气滋肾冲剂(简称中药)对IgA肾病的治疗作用机理。方法:取小鼠150只,随机分为5组。各治疗组在造模的同时给予相应治疗药物,分别于第3、6、9、12周处死小鼠,用光镜、电镜观察各组小鼠肾小球病理变化及其超微结构。结果:模型组小鼠第6、9、12周时肾小球系膜细胞、系膜基质明显增生,肾小球光密度、系膜区面积、系膜细胞数密度、系膜基质光密度均呈显著增高;中药大、小剂量组和阳性药组小鼠病理程度较模型组轻。中药大剂量组的肾小球光密度、系膜细胞数密度、系膜基质光密度、系膜区面密度显著低于模型组(P<005或P<001)。结论:益气滋肾冲剂能明显地抑制IgA肾病肾小球系膜细胞和系膜基质的增生。Objective: To study the effect and therapeutical mechanism of Yiqi Zishen granule (YQZSG) in treating IgA nephropathy. Methods: One hundred and fifty mice were divided into 5 groups randomly, in every treatment group, the relevant drugs were given. Their kidney tissues were observed with light microscope and electron microscope in batches at the 3th ,6th, 9th and 12th week. Results: The glomerular mesangial cells and mesangial matrix were proliferative in the model group at the 6th, 9th and 12th week. The light density of glomeruli, the mesangial area, the numeral density of mesangial cells and the light density of mesangial matrix in the model group were obviously higher, the change of large and small dosage YQZSG group and positive Chinese drug group were similar, but milder in pathological degree. The light density of glomerulus area, the mesangial area, the numeral density of mesangial cells and the light density of mesangial matrix in large dosage YQZSG group were significantly lower than those in the model group (P<0 05 or P<0 01). Conclusion: YQZSG could inhibit the proliferation of mesangial cells and the mesangial matrix in IgA nephropathy.

关 键 词：益气滋肾冲剂 IGA肾病 肾小球超微结构 

分 类 号：R289.5[医药卫生—方剂学] R285.5[医药卫生—中药学]