碳酸钙和生物钙对大鼠废用性骨质疏松症的作用  

Effects of calcium carbonate and biological calcium on disuse osteoporosis in rats

作　　者：张永喜[1] 高倩[1] 刘玉府[1] 杨坤[1] 孔小娟 张静涵 李万里[1] 田玉慧[1] 桂立辉[1] 

机构地区：[1]新乡医学院,453003

出　　处：《新乡医学院学报》1999年第4期306-307,共2页Journal of Xinxiang Medical University

基　　金：新乡医学院第二届大学生科研资助

摘　　要：目的　探讨碳酸钙和生物钙对废用性骨质疏松大鼠骨密度的影响，指导人们正确合理的补钙，为骨质疏松的防治提供依据。方法　２ｍｏ 龄健康ＳＤ 大鼠５０ 只，随机分为５ 组，雌雄各半。２ ～５ 组复制骨质疏松动物模型，１～２ 组喂普通饲料，３ ～５ 组喂加钙饲料。饲养２ｍｏ 后测各组动物的骨密度及血钙、血锌等指标。结果　骨质疏松动物模型复制成功，各补钙组间大鼠骨密度及血钙、血锌无显著性差异。结论　补各种类型的钙对骨质疏松的预防均有一定的作用，而补碳酸钙更加经济合理。Objective To find out the evidence of prevention and treatment of osteoporosis to give advice on how to supplement calcium reasonably, the effects of Biological calcium and calcium carbonate on the bone mineral density(BMD) in disuse osteoporosis rats were investigated. Methods Fifty healthy SD rats (2-month old ) were randomly divided into 5 groups, half male and half female. Group2,3,4 and5 were reproduced with patterns of animal osteoporosis. The diet in group 1 and group 2 was the basic diet, while the three experiment diets were supplemented with calcium. BMD, serum calcium and serum zinc were measured two months later. Results The patterns of animal osteoporosis were proved to be successful. The different forms of calcium in diet had no significant effect on the BMD ,serum calcium and serum zinc. Conclusions The calcium supplement has certain effects on the prevention of osteoporosis. The calcium carbonate is the most economic one and the ideal calcium source for supplementation.

关 键 词：骨质疏松 骨密度 碳酸钙 生物钙 大鼠 

分 类 号：R681[医药卫生—骨科学] R977.5[医药卫生—外科学]