^(153)Gd衰减校正对门控心肌断层显像测定左室心功能参数的影响  

^(153)Gd attenuation corrected ^(99m)Tc-MIBI gated myocardial perfusion single photon emission tomography for the assessment of left ventricular function

作　　者：冯建林[1] 赵中强[1] 袁冬兰[1] 周艳丽[2] 李殿富[2] 

机构地区：[1]南京医科大学第一附属医院核医学科,江苏南京210029 [2]南京医科大学第一附属医院心脏科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2011年第8期1216-1219,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省卫生厅2008年度"六大人才高峰"D类资助(2008073)

摘　　要：目的:探讨153Gd衰减校正(AC)处理对99mTc-甲氧基异丁基异腈(MIBI)门控心肌断层显像(G-SPECT)测定左室心功能参数的影响。方法:69例疑为冠心病患者,均行99mTc-MIBI静息G-SPECT,分别用AC和非衰减校正(NC)处理,测得舒张末期容量(EDV)、收缩末期容量(ESV)、左室射血分数(LVEF),所有患者在1～4周内行二维超声心动图(2-DE)检查测定LVEF,比较AC、NC和2-DE测得LVEF的相关性。结果:①NC和AC测得EDV、ESV分别为(79.6±33.4)ml、(33.8±29.9)ml和(87.4±34.8)ml、(36.7±31.9)ml,它们之间的相关性良好(rEDV=0.99,y=1.04x+4.73;rESV=0.99,y=1.06x+0.79;P均<0.01),但AC测得的EDV、ESV均>NC(P均<0.01);②NC和AC测得LVEF分别为(60.3±9.2)%、(60.8±9.9)%,它们之间的相关性良好(r=0.98,y=1.02x-1.04,P<0.01),且两者间没有统计学差异(P>0.05);③2-DE测得的LVEF为(54.6±8.9)%,<NC、AC测得的LVEF(P均<0.01),但它们之间的相关性良好(rNC=0.88,y=0.91x+10.81;rESV=0.81,y=0.87x+13.10;P均<0.01)。结论:AC处理99mTc-MIBI G-SPECT测得的LVEF准确、可靠,和NC、2-DE测得的LVEF相关性良好。Objective：To evaluate the attenuation corrected（AC） 99m Tc-MIBI gated myocardial perfusion single photon emission tomography（G-SPECT） for the assessment of left ventricular ejection fraction（LVEF）.Methods：Total 69 patients probably with coronary artery disease were enrolled in this study.All of them underwent resting G-SPECT and two dimensional echocardiography（2-DE）.Left ventricular ejection fraction（LVEF）,left ventricular end-diastolic volume（EDV） and left ventricular end-systolic volume（ESV） were acquired from attenuation corrected and non-attenuation corrected（NC） 99m Tc-MIBI G-SPECT and 2-DE.T test and correlation analysis were used to compared the parameter of heart function.Results： ① EDV and ESV measured by AC and NC G-SPECT were（79.6 ± 33.4） ml and（87.4 ± 34.8） ml（P 〈 0.01）,and（33.8 ± 29.9） ml and（36.7 ± 31.9） ml（P 〈 0.01）.EDV and ESV measured by AC were positively correlated with EDV and ESV measured by NC（r EDV = 0.99,y = 1.04x ＋ 4.73,P 〈 0.01;r ESV = 0.99,y = 1.06x ＋ 0.79,P 〈 0.01）.② LVEF determined by AC and NC G-SPECT were（60.3 ± 9.2）% and（60.8 ± 9.9）%.No statistical significance was observed between them.However,the positive correlation was found between them（r = 0.98,y = 1.02x-1.04,P 〈 0.01）.③ LVEF measured by 2-DE was（54.6 ± 8.9）%,which was markedly lower than them determined by AC and NC（P 〈 0.01）.There were positive correlation between them（r NC = 0.88,y = 0.91x ＋ 10.81,P 〈 0.01;r ESV = 0.81,y = 0.87x ＋ 13.10,P 〈 0.01）.Conclusion：LVEF measured by AC G-SPECT,which is accurate and reliable,correlates well with LVEF determined by NC G-SPECT and 2-DE.

关 键 词：衰减校正 门控血池显像 左室射血分数 MIBI 

分 类 号：R817.4[医药卫生—影像医学与核医学]