毛细管电泳涂层研究进展  

Research Progress of Capillary Electrophoresis Coatings

作　　者：于冰[1,2] 刘鹏[1] 丛海林 张立新[1] 张江涛[1] 

机构地区：[1]青岛大学化学化工与环境学院,山东青岛266071 [2]现代纺织国家重点实验室培育基地,山东青岛266071

出　　处：《分析测试学报》2011年第8期945-952,共8页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目(21004035,21005042);山东省自然科学基金资助项目(ZR2010BQ020);山东省优秀中青年科学家科研奖励基金资助项目(BS2010CL014)

摘　　要：近年来,随着毛细管电泳与质谱、激光诱导荧光检测等联用技术的飞速发展,毛细管电泳技术在生命科学、环境保护、食品检验等领域得到广泛应用。对毛细管内壁进行涂层改性是提高毛细管电泳的分离效果和重现性,抑制分析物与毛细管内壁间吸附作用的最有效、最常用的方法。该文根据涂层材料的种类和制备机理,分别综述了近年来非共价键合和共价键合毛细管涂层的最新研究进展,对不同类型涂层材料进行了比较,并对未来的发展方向做了展望。In recent years,accompanied by the extraordinarily rapid developments in the capillary electrophoresis（CE） online coupling techniques with mass spectrometry（MS） and laser-induced fluorescence（LIF） spectrometry,CE has been widely used in the areas of life science,environmental protection and food detection.In order to suppress the adsorption of analytes onto the capillary surface and enhance the separation performance and repeatability,coating the capillary column with functional materials becomes the most efficient and commonly used approach.In this paper,the latest progress about covalent and non-covalent bonded capillary coatings is reviewed based on the different materials and preparation mechanisms of the capillary coatings.The difference of coatings are compared,and the future direction of coating development is discussed.

关 键 词：毛细管电泳 毛细管涂层柱 非共价键合涂层 共价键合涂层 

分 类 号：O657.8[理学—分析化学] G353.11[理学—化学]