昆明山海棠抗生育活性提取物TH_5对雄性大鼠性行为与血清性激素水平影响的观察  

Observation of effection on the sexual behavior and serum sex hormone level by antifertility active TH_5 extract in male rats

作　　者：周激文[1] 李文琦[1] 潘汝能 刘黎闻 李欣[1] 罗宁云 张宪民 

机构地区：[1]云南省计划生育技术科学研究所,昆明650021 [2]中科院昆明植物研究所

出　　处：《中国男科学杂志》1999年第4期211-213,共3页Chinese Journal of Andrology

摘　　要：为了开发避孕新药，本文报告昆明山海棠抗生育活性提取物ＴＨ５ 对Ｗｉｓｔａｒ 成年雄性大鼠抗生育试验的性行为观察与血清性激素水平。灌服ＴＨ５（１１６ ｍｇ／ｋｇ·ｄ－ １ ×３０ ｄ） 的雄性大鼠与未交配过的成年雌性大鼠合笼后，其阴栓与阴道涂片精子检出率及服药雄鼠的血清Ｔ、ＬＨ、ＦＳＨ之ＲＩＡ 测定值，和对照大鼠组相比均无统计学差异（ Ｐ＞ ０．０５） ，表明ＴＨ５ 可能并不干扰受试雄鼠的性欲与血清性激素水平。To exploit new medicine of male contraception,We observed that the sexual behavior and serum sex hormone of adult male rats after given TH 5 (116 mg/kg/d x30 d)extract from Tripterygium hypoglaucum(Levl.)Hutch.No difference was found in positive rates of sperm in vaginal plug and smear as well as serum T,LH and FSH level between experiment groups and control groups ( P >0.05).It shows that TH 5 does not disturbe the sexual behavior and serum sex hormone levels of male experimental rats.

关 键 词：昆明山海棠 TH5 性行为 性激素 雄性大鼠 

分 类 号：R169.41[医药卫生—公共卫生与预防医学] R282.710.5