矽肺患者血清转化生长因子-β1和肿瘤坏死因子-α的变化  

Change of serum TGF-β1 and TNF-α in silicosis patients

作　　者：缪荣明 张雪涛[2] 严于兰 何恩奇[3] 郭平 张颖轶 赵道昆 杨志刚 陈洁 姚明莺 赵锐 房中华 姚雍铭 

机构地区：[1]无锡市职业病防治医院职业病科,214002 [2]上海市杨浦区中心医院职业病科 [3]无锡市疾病预防控制中心

出　　处：《中华劳动卫生职业病杂志》2011年第8期606-607,共2页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：基金项目：无锡市卫生科研基金项目（XM0909）

摘　　要：目的观察矽尘接触者和矽肺患者及观察对象血清转化生长因子-β1（TGF-β1）和肿瘤坏死因子-α（TNF-α）水平，探讨TGF-β1、TNF—α在矽肺发生发展中的作用。方法选择100名不接触粉尘的对照人群（对照组），200名接触矽尘1年以上的接尘工人（接尘组），32名矽尘作业观察对象（0^±）（观察对照组）及130例矽肺患者（矽肺组），采用ELISA法检测其血清TGF-β1和TNF—α水平。结果与对照组[（6．90±2．24）pg／ml]比较，接尘组、观察对象组和矽肺组TNF-α水平[（47．86±16．52）、（109．11±31．08）、（216．35±51．03）pg／ml]明显升高，差异有统计学意义（P〈0．01）；与接尘组比较，观察对象组和矽肺组TNF-α水平明显升高，差异有统计学意义（P〈0．05，P〈0．01）。与对照组[（23．28±12．24）pg／ml]和接尘组[（29．31±14．52）pg/ml]比较，观察对象组和矽肺组TGF-β1水平[（46．16±17．35）、（58．36±31．94）pg／ml]明显升高，差异有统计学意义（P〈0．05，P〈0．01）。结论TGF—β1和TNF-α在矽肺发生发展中有重要作用，检测外周血TGF—β1和TNF-α水平可应用于职业健康监护及矽肺的早期诊断。Objective To observe serum TGF-β1 and TNF-α in silicosis patients and workers exposed to silica dust to study the role of TGF-β1 and TNF-α in the development of silicosis. Methods One hundred non-exposed workers were selected as control group, 200 workers exposed to silica dust for more than 1 year as exposed group, 32 suspected silicosis patients （originally diagnosed as 0^＋） as observing group, 130 silicosis patients were as silicosis group. Serum TGF-β1 and TNF-α in each group were determined with ELISA. Results Serum TNF-α in exposed group[（47.86±16.52） pg/ml], observing group[（109.11±31.08） pg/ml], silicosis group [（216.35±51.03） pg/ml] were significantly higher than that in control group [（6.90±2.24） pg/ml] （P〈0.01）; Silicosis group and observing group were also higher than exposed group （ P〈0.01, P〈0.05）.Compared with control group [（23.28±12.24） pg/ml] and exposed group [（29.31±14.52）pg/ml], serum TGF-β1 in silicosis group was much higher （P〈0.01）. Conclusion TGF-β1 and TNF-α were essential in the development of silicosis, so the detection of TGF-β1 and TNF-α in peripheral blood was very useful for occupational health surveillance and early diagnosis of silicosis.

关 键 词：矽肺 转化生长因子-Β1 肿瘤坏死因子-Α 

分 类 号：R285.5[医药卫生—中药学]