等效罗库溴铵、美维松和琥珀胆碱用于气管插管及临床药效分析  

Comparison of Recuronium, Mivacurium and Succinylcholoine in Endotracheal Intubation and Clinical Pharmacodynamics.

作　　者：余革[1] 欧阳葆怡[1] 董庆龙[1] 

机构地区：[1]广州医学院第一附属医院麻醉科,广州510120

出　　处：《华中医学杂志》1999年第6期242-244,共3页Central China Medical Journal

摘　　要：成年手术患者45例,随机分成三组,每组15例.给予罗库溴铵(Ⅰ组)、美维松(Ⅱ组)和琥珀胆碱(Ⅲ组),待拇收肌诱发颤搐反应的T_1达到最大抑制时行气管插管,监测肌松药的抑制时程和恢复过程.结果插管评级达到1级者,Ⅰ、Ⅱ、Ⅲ组分别为11、8、3例,2级为4、7、9例,Ⅲ组3级2例和4级1例,Ⅲ组插管评级比Ⅰ、Ⅱ组差(P<0.01);三组T_1最大抑制程度相同(P>0.05),但达到最大抑制时间Ⅲ组最快、Ⅰ组其次、Ⅱ组最慢(P<0.01);三组T_1恢复过程比较,Ⅲ组最快,Ⅱ组其次,Ⅰ组最慢(P<0.01).Forty-five adult patients were equally divided into three groups depending on administering different muscle relaxants: group Ⅰ , rocuronium; group Ⅱ , mivacurium;and group Ⅲ ,succinylcholine. The endotracheal intubation was performed after the maximal depression of T1 achieved. The TOFr and T1 were measured by using accelography in addcutor pollicis. The onset time,duration of blockade,recovery of TOFr and recovery index were observed ;The patients with excellent or good results of endotracheal intubation condition in the three groups were 11,8,3 and 4,7,9 cases respectively .but 2 cases were poor and 1 case was impossible in the group Ⅲ . Endotracheal intubation results in groups Ⅰ and Ⅱ were better than in group Ⅲ (P <0. 01). The time of maximal depression of T1 occurred at 2. 68,5. 32 and 1. 50 min and the recovery index were 9. 30,7. 04 and 1. 56 min in the three groups respectively(P<0. 01).

关 键 词：罗库溴铵 美维松 琥珀胆碱 气管插管 药效分析 

分 类 号：R971.2[医药卫生—药品]