温郁金抗抑郁活性部位的筛选  

Screening of antidepressant fractions of Wenyujin

作　　者：赵铮蓉[1] 张萍[1] 吴月国[1] 刘骅[1] 

机构地区：[1]浙江省医学科学院,杭州310013

出　　处：《中华中医药杂志》2011年第8期1868-1869,共2页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:筛选温郁金抗抑郁活性部位。方法:选用小鼠行为绝望模型评价温郁金醇提取物及其不同极性部位的抗抑郁作用。结果:温郁金醇提取物及其4个不同极性部位均不同程度地缩短绝望模型中小鼠悬尾和强迫游泳的不动时间。其中以温郁金醇提取物(P<0.01)、石油醚部位(P<0.001)和乙酸乙酯部位(P<0.01)最为显著。结论:温郁金具有抗抑郁作用,活性成分主要分布在石油醚和乙酸乙酯部位。Objective：To screen the antidepressant fractions of Wenyujin.Methods：Behavioral despair models in mice were used to evaluate antidepressant activities of the antidepressant fractions of Wenyujin.Results：The extract of Wenyujin and its four fractions were able to elicit time-dependent reducing of duration of immobility in the tail suspension test and the forced swimming test in mice.Among these test samples,the extract of Wenyujin（P0.01）,petrol fraction（P0.001） and ethyl acetate fraction（P0.01） were more potent.Conclusion：Wenyujin has antidepressant effect.The active parts are in petrol fraction and ethyl acetate fraction.

关 键 词：温郁金 抗抑郁 悬尾应激 强迫游泳 

分 类 号：R285.5[医药卫生—中药学]