肝病患者不同血瘀证TXB2/6-keto-PGF1α的临床实验研究  

Clinial study on TXB2/6-keto-PGF1α of different blood-stasis syndromes

作　　者：武哲丽[1] 陈群[1] 刘梅[1] 莫传伟[1] 王剑[1] 路艳[1] 

机构地区：[1]广州中医药大学,广州510006

出　　处：《中华中医药杂志》2011年第8期1878-1880,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家"十一五"科技支撑计划课题(No.2006BAI08B01-3);广东省科技计划项目(No.2009B060700121)~~

摘　　要：目的:从分子水平探讨肝病患者不同血瘀证及其形成的病理机制。方法:采用前瞻性研究的方法进行肝病瘀血舌患者血液血栓素B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)的测定。结果:肝病各组的TXB2显著增高(P<0.01),6-keto-PGF1α显著降低(P<0.05,P<0.01)。TXB2/6-keto-PGF1α显著增高(P<0.01);不同肝病血瘀证组与正常组的TXB2、6-keto-PGF1α、TXB2/6-keto-PGF1α的比较有显著性差异(P<0.01),湿热瘀滞、肝瘀痰阻、气滞血瘀的TXB2、6-keto-PGF1α、TXB2/6-keto-PGF1α与气虚血瘀组比较有显著差异(P<0.01)。结论:肝病及不同血瘀证组的TXB2与TXB2/6-keto-PGF1α显著增高,6-keto-PGF1α显著降低,说明血浆TXA2-PGI2平衡失调与血瘀证发生发展密切相关,通过测定TXB2、6-keto-PGF1α的含量可以反映肝病瘀血舌象及其不同血瘀证的发生机制。Objective：To explore the pathology mechanism of hepatopathy tongue of blood stasis（TBS）on molecule level.Methods：Tongue of blood stasis of hepatopathy TBS and blood stasis syndrome and mechanism of their formation were probed by means of the test of molecular and prospective study.Results：TXB2 and TXB2 /6-keto-PGF1α of all the hepatopathy group were risen significantly compared with normal group（P0.01）,6-keto-PGF1α of all the hepatopathy group were sharp dropped compared with normal group（P0.01）;On the indexes of TXB2 and TXB2 /6-keto-PGF1α,there was significant difference between BSS group and normal group（P0.01）,there was very marked difference between Qi deficiency and blood stasis syndrome（QDBSS）and the others（P0.01）.Conclusion：TXB2 and TXB2 /6-keto-PGF1α of all the hepatopathy group and BSS group are risen significantly compared with normal group,6-keto-PGF1α was dropped significantly,the balance inorder of TXA2 and PGI2 blood plasma is closely bound up with development and consequences of BSS,the content of TXB2 and 6-keto-PGF1α may reflect the mechanism of their formation between tongue of blood stasis of hepatopathy and blood stasis syndrome.

关 键 词：治未病 瘀血舌象 血栓素B2/6-酮-前列腺素F1α 实验研究 

分 类 号：R285.6[医药卫生—中药学]