响应面分析法优化加速溶剂萃取焦当归中5-羟甲基糠醛的工艺  

Optimization of Accelerated Solvent Extractionfor 5-HMF in Coke Angelicae Sinensis withResponse Surface Analysis

作　　者：周桂芬[1] 郑珊娇[2] 

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]温州医学院,浙江温州325035

出　　处：《中华中医药学刊》2011年第8期1900-1903,共4页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:优化加速溶剂萃取(ASE)焦当归中5-羟甲基糠醛的最佳工艺参数。方法:选取焦当归5-羟甲基糠醛的加速溶剂萃取条件:萃取温度、静态萃取时间和静态循环次数3个因素进行Box-Benhnken中心组合设计,利用响应面分析法对其提取工艺参数进行优化,并与回流提取法和超声提取法进行比较。结果:通过优化并经实验验证,得出加速溶剂提取法提取焦当归中5-羟甲基糠醛的最佳试验参数为:加热温度50℃、静态萃取时间12m in和静态循环次数为1次。结论:与传统方法相比,ASE提取法具有方便、省时、提取效率高等优点。Objective：To optimize the parameters of accelerated solvent extraction（ASE） for 5-hydroxymethyl furadehyde（5-HMF）in coke Angelicae Sinensis.Methods：The conditions of ASE for 5-HMFin cokeAngelicae Sinensis,including static extractiontime,extractiontemperature and static cycle times,were investigated with a three-factor Box-Benhnken center-uniteddesign.The extractionparameters were optimized with response surface analysis.Results：The optimum conditions are as follows： extraction temperature 50℃,static extractiontime12min,static cycle times1 times.Concluson：Compared with traditional extraction technique such as reflux extraction and ultrasonic extraction,ASE is more convenient,effective and quick.

关 键 词：加速溶剂萃取 焦当归 5-羟甲基糠醛 响应面法 

分 类 号：R284[医药卫生—中药学]