PLMT家族成员SET7/9的非组蛋白甲基化作用  

Methylation of non-histone proteins by SET7/9,a member of PLMT family

作　　者：高丽丽[1] 余卫平[1] 

机构地区：[1]水东南大学医学院病理学与病理生理学系,南京210009

出　　处：《生命科学》2011年第8期773-778,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81071654)

摘　　要：SET7/9是蛋白赖氨酸甲基化转移酶(protein lysine methyltransferases,PLMTs或PKMTs)家族成员,具有SET结构域。现已发现SET7/9是一种赖氨酸单甲基化转移酶,除了能使组蛋白H3第四位赖氨酸(lysine4 of histone 3,H3K4)单甲基化外,更重要的能使一些转录因子、肿瘤抑制因子、膜相关受体等非组蛋白单甲基化,其甲基化作用主要与蛋白稳定和转录活化有关。该效应受赖氨酸特异性去甲基酶1(lysine specifcdemethylase,LSD1)的抑制。SET7/9与LSD1两者效应的平衡对维持体内活性蛋白质含量、调节基因表达具有重要意义。SET7/9 is a member of protein lysine methyltransferase family.It contains a SET domain.Recent studies demonstrate that SET7/9 methylates both lysine 4 of histone 3（H3-K4） and lysine（s） of non-histone proteins including transcription factors,tumor suppressor and membrane-associated receptors,so on.SET7/9 is exclusively a monomethyltransferase,and it is mainly related to protein stabilization and transcriptional activation.Additionally,mathylation by SET7/9 can be blocked by lysine specifc demethylase 1（LSD1）.Thus,the equilibrium of effects between SET7/9 and LSD1 is important to maintain the content of some active proteins and to regulate the expression of some genes.

关 键 词：SET7/9 赖氨酸甲基化转移酶 非组蛋白 甲基化作用 

分 类 号：Q52[生物学—生物化学] Q344.14