组蛋白去甲基化酶JMJD1A  

Advances in histone demethylase JMJD1A

作　　者：郭晓强[1] 王越甲[2] 沈永青[2] 刘贝[2] 段相林[2] 

机构地区：[1]解放军白求恩军医学院生化教研室,石家庄050081 [2]河北师范大学生命科学院,石家庄050016

出　　处：《生命的化学》2011年第4期484-487,共4页Chemistry of Life

基　　金：国家自然科学基金资助项目(38070265);河北省自然基金项目(C2010000410)资助

摘　　要：组蛋白翻译后修饰可影响特定基因的表达,从而在多个生理过程中发挥重要作用,是当前生命科学领域的研究热点之一。组蛋白去甲基化酶JMJD1A可催化一甲基化和二甲基化的H3K9(H3K9me1/2)去甲基化,通过解除组蛋白抑制效应而调节基因表达。JMJD1A拥有广泛的生物学功能,参与多种生物学过程包括核受体激活、精子生成、能量代谢、低氧调节和癌症发生等。本文就JMJD1A的特征及功能作一综述。Histone post-translational modifications can affect specific genes expression,which plays an important role in many physiological processes and is one of the intense research area in current life sciences.Histone demethylase JMJD1A(Jumonji domain-containing protein 1A) regulates gene expression by catalyzingdemethylation of mono-and di-methy H3K9(H3K9me1/2).JMJD1A has important biological functions in many physiological processes,such as nuclear receptor activation,sperm development,energy metabolism,hypoxic regulation and carcinogenesis.In this review,the properties and functions of JMJD1A were discussed.

关 键 词：组蛋白去甲基化酶 JMJD1A 核受体 低氧 癌症发生 

分 类 号：Q51[生物学—生物化学]