核糖体蛋白质的新功能及其与相关疾病的关系  

The extraribosomal functions of ribosomal proteins and the related diseases

作　　者：田媛[1] 张俊平[1] 

机构地区：[1]第二军医大学药学院生化药学教研室,上海200433

出　　处：《生命的化学》2011年第4期488-491,共4页Chemistry of Life

摘　　要：核糖体蛋白质与核糖体RNA共同组成了核糖体,是合成蛋白质的细胞器。除参与蛋白质合成,核糖体蛋白质还具有广泛的核糖体外功能,如独立于核糖体外发挥调控基因转录、mRNA翻译、细胞的增殖、分化和凋亡等等。基于诸多的核糖体外功能,核糖体蛋白质与人类疾病密切相关,例如在先天性贫血、生长发育不全和肿瘤的发生发展过程中均发挥重要作用。本文对近年来核糖体蛋白质的核糖体外新功能及其相关疾病的研究进展作一综述。As the organism responsible for new protein synthesis in cells,ribosome is composed of ribosomal protein and ribosomal RNA.Besides of new proteins synthesis,there are lots of extraribosomal functions for ribosomal proteins.For example,they can regulate gene transcription,mRNA translation,cell apoptosis and so on.Based on these extraribosomal functions,ribosomal proteins are related to many diseases,such as Diamond-Blackfan anemia,hypoplasia and cancer.In this paper,recent research developments were reviewed concerning extraribosomal functions and related diseases.

关 键 词：核糖体蛋白质 核糖体外功能 

分 类 号：Q51[生物学—生物化学]