心脏标志物的检测在早期急性心肌梗死诊断中的临床意义  

作　　者：黄金[1] 梁庆华[1] 

机构地区：[1]广西壮族自治区江滨医院检验科,广西南宁530021

出　　处：《中国民族民间医药》2011年第15期30-30,32,共2页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:探讨肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)、肌红蛋白(Mb)对诊断急性心肌梗死(AM I)的临床意义。方法:采用免疫抑制法、化学发光法检测80例AM I患者(实验组),血清CK-MB、cTnI、Mb,并与80例非AM I患者(对照组)比较。结果:实验组血清CK-MB、cTnI、Mb浓度均高于对照组,且两组比较具有显著性差异(P<0.05)。CK-MB诊断AM I的特异性为71.62%,敏感性为89.24%;cTnI的特异性为96.21%,敏感性为85.62%;Mb的特异性为94.32%,敏感性为86.21%。结论:联合检测CK-MB、cTnI、Mb对于早期诊断和治疗急性心肌梗死具有积极重要作用。Objective： To explore the clinical significance of detecting creatine kinase isozymes （ CK - MB）, cTnI （cTnI） and muscle red protein （Mb） to diagnosis acute myocardial infarction （AMI）. Methods： The concentration of CK -MB, cTnI and Mb from both observed group （including 80 patients with AMI） and control group （including 80 patients without AMI） were detected by the immune suppression and chemiluminescence method and the results were analisied. Results： the serum CK - MB, eTnI, MB in the observed group were all higher than those in the control group, and two groups of comparisons had significant difference （ P 〈 0. 05）. The specificity and sensitivity of CK - MB were 71.62% and 89. 24%, respectively; The specificity and sensitivity of cTnI were 96. 21% and 85.62%, respectively; The specificity and sensitivity of Mb were 94. 32% and 86. 21%, respectively. Conclusions： It was imoortant to detect CK- MB, eTnI, Mb assoeiatedly to diagnosis and treat acute myocardial infarction early.

关 键 词：急性心肌梗死 肌酸激酶同工酶 肌钙蛋I 肌红蛋白 

分 类 号：R542.22[医药卫生—心血管疾病]