弯茎还阳参石油醚部位化学成分研究  

Studies on the Chemical Constituents from Crepis flexuosa with Petrolelum Ether

作　　者：林小燕[1] 张婉春[1] 石冬梅[1] 陆真真[1] 张永红[1] 

机构地区：[1]福建医科大学药学院,福州350004

出　　处：《福建医科大学学报》2011年第3期197-200,共4页Journal of Fujian Medical University

基　　金：福建省自然科学基金(2010J01179);福建省教育厅科研基金(JS06025)

摘　　要：目的研究弯茎还阳参Crepis flexuosa全草的化学成分。方法采用硅胶及Sephadex LH-20柱层析进行分离纯化,通过理化性质和光谱分析鉴定结构。结果从弯茎还阳参中分离得到10个化合物,分别鉴定为木栓酮（friedelin,1）,α-香树素（α-amyrin,2）,β-香树素（β-amyrin,3）,α-香树素乙酸脂（α-amyrin acetate,4）,β-香树素乙酸酯（β-amyrin acetate,5）,蒲公英甾醇乙酸酯（taraxasteryl acetate,6）,齐墩果酸（oleanolic acid,7）,β-谷甾醇（β-sitosterol,8）,软脂酸（pal mitic acid,9）和正三十烷烃（triacontane,10）。结论从弯茎还阳参植物中首次分离得到化合物1~10,其中化合物1和7为首次从还阳参属植物中分离得到。Objective To study the chemical constituents of whole plant of Crepis flexuosa（DC.） Benth.et Hook.f.Methods Separation and purification were performed on silica gel and Sephadex LH-20 CC.Their structures were established on the basis of physicochemical and spectral analysis.Results Ten compounds were isolated and identified as friedelin（1）,α-amyrin（2）,β-amyrin（3）,α-amyrin acetate（4）,β-amyrin acetate（5）,taraxasteryl acetate（6）,oleanolic acid（7）,β-sitosterol（8）,palmitic acid（9） and triacontane（10）,respectively.Conclusion Compounds 1-10 were isolated from the plant for the first time.Compounds 1,7 were obtained from Crepis L.for the first time.

关 键 词：弯茎还阳参 菊科 中药化学成分 三萜 光谱分析 

分 类 号：R284[医药卫生—中药学]