超声造影定量评价YC-1治疗疗效的实验研究  

Quantitative Analysis of Contrast-enhanced Ultrasound in the Evaluation of YC-1 Antiangiogenesis Effect

作　　者：张会萍[1] 都伟丽[2] 李凡[1] 史秋生[1] 杜联芳[1] 吴晴[2] 

机构地区：[1]上海交通大学附属上海市第一人民医院超声科,上海市200080 [2]上海交通大学附属上海市第一人民医院肿瘤科,上海市200080

出　　处：《中国超声医学杂志》2011年第8期676-679,共4页Chinese Journal of Ultrasound in Medicine

基　　金：上海市级医院适宜技术联合开发推广应用项目(No.SHDC12010221);上海市科委科技攻关计划项目(No.10411951800)

摘　　要：目的探讨超声造影定量分析评价YC-1抗血管生成治疗人胃癌裸鼠移植瘤后瘤内血供变化情况的价值。方法建立人胃癌SGC7901/DDP细胞株裸鼠皮下移植瘤模型,随机分为对照组、DDP组、YC-1组和YC-1+DDP组,各组按实验设计给药。停药1周后行超声造影检查及定量分析。每个肿瘤画2个ROI:ROI_(total)包含整个肿瘤,ROI_(small)包含肿瘤中造影增强最强的部分。记录造影参数A2、A3、TTP、PI、AT、AUC、R10、R20、R30及V。比较各参数组间差异。结果对于RO_(total)各参数在各组间差异无统计学意义(P>0.05)。对于ROI_(small),参数A2、TTP、AUC、R10、R20及R30在各组间差异有统计学意义(P<0.05)。结论超声造影定量分析可有效反映YC-1抗血管生成治疗后肿瘤内血供的变化,为肿瘤抗血管生成治疗疗效评价提供新方法。Objective To explore the value of contrast-enhanced ultrasound quantitative analysis on the evaluation of blood supply change of transplanted tumor of human gastric carcinoma in nude mice after YC-1 antiangiogenesis treatment. Methods The transplanted tumor model of human gastric carcinoma in nude mice was establshed by injecting SGC7901/DDP-resistant cells into the subcutaneous space of 24 nude mice. The mice were randomized into four groups as control group, DDP group, YC-1 group and YC-I＋DDP group. The medicine was given to each mouse for two weeks according to the experimental design. Contrast-enhanced ultrasound and quantitative analysis were performed to each mouse one week after withdrawl. For each tumor, ROItotal including the whole tumor and ROIsmall including the highest-enhanced part of the tumor were drawn and parameters including A2, A3, TTP, PI, AT, AUC, R10, R20, R30 and V were recorded for statistical analysis. Results For ROItotal, no parameter had significant difference among the four groups. For ROIsm,n, parameters A2, TTP, AUC, R10, R20 and R30 had significant difference among the four groups. Conclusions Contrast-enhanced ultrasound quantitative analysis reflects the blood supply change on transplanted tumor of human gastric carcinoma in nude mice after YC-1 antiangiogenesis treatment. It could be used as a new method to assess therapeutic effects of tumor antiangiogenesis treatment.

关 键 词：超声 微泡 定量分析 抗血管生成 

分 类 号：R445.1[医药卫生—影像医学与核医学]