前列地尔联合甲钴胺辅治糖尿病周围神经病变的疗效观察  

The effect observation of alprostadil combined with mecobalamine in diabetic peripheral neuropathy

作　　者：佟爱华[1] 

机构地区：[1]山东省临沂市沂水中心医院,276400

出　　处：《临床合理用药杂志》2011年第17期15-16,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察前列地尔联合甲钴胺辅治糖尿病周围神经病变(DPN)的临床疗效。方法将DPN患者80例随机分成治疗组42例和对照组38例。在控制血糖基础上,对照组给予甲钴胺500μg肌内注射,每天1次,连续14d;治疗组在对照组治疗基础上加用前列地尔10μg+生理盐水100ml静脉滴注,每天1次,连续14d。观察2组临床疗效及治疗前后神经传导速度。结果治疗组总有效率为97.6%高于对照组的65.8%,差异有统计学意义(P<0.05)。2组治疗后正中神经和腓总神经运动传导速度(MCV)及感觉传导速度(SCV)均快于治疗前(P<0.05);且治疗组治疗后正中神经和腓总神经MCV及SCV均快于对照组(P<0.05)。结论前列地尔联合甲钴铵辅治DPN,对神经传导速度及症状、体征的改善均有良好作用,且无明显不良反应,值得推广应用。Objective To investigate the efficacy of alprostadil combined with mecobalamine in diabetic peripheral neuropathy（DPN）.Methods 80 cases patients with DPN were randomly divided into the treatment group（n=42） and the control group（n=38）.Based on the basic control of blood glucose,the control group were given intramuscular injection of mecobalamine 500μg,once a day,continuous 14d;The treatment group based on the control group were treated alprostadil 10μg＋normal saline 100ml intravenous infusion,one time a day,continuous 14d.Observed treatment effect and before and after the nerve conduction velocity of two groups.Results The total effective rate of the treatment group（97.6%） was higher than that of the control group（65.8%）,the difference was statistically significant（P0.05）.After treatment,MCV and SCV of median nerve and common peroneal nerve of two groups were faster than those before treatment（P0.05）;And after treatment,the MCV and SCV of median nerve and peroneal nerve were faster than those of the control group（P0.05）.Conclusion Alprostadil combined mecobalamine in DPN,on nerve conduction velocity and symptoms,signs of improvement has a good effect,and no significant adverse reaction,should be widely application.

关 键 词：糖尿病 糖尿病周围神经病变 前列地尔 甲钴胺 

分 类 号：R587.2[医药卫生—内分泌]