溴新斯的明1日2次缓释片的工艺优化及体外释放特性  

Study on preparation and in-vitro release of neostigmine bromide sustained-release tablets

作　　者：廖娟[1] 谭群友[2] 熊华蓉[1] 陶绍林[2] 张景勍[1] 

机构地区：[1]重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室,重庆400016 [2]第三军医大学大坪医院野战外科研究所胸外科,重庆400042

出　　处：《重庆医科大学学报》2011年第6期711-713,共3页Journal of Chongqing Medical University

基　　金：教育部博士点基金资助项目(编号:20095503120008);重庆市教育委员会资助项目(首批高等学校优秀人才资助;编号:KJ090308)

摘　　要：目的:优化溴新斯的明1 d 2次缓释片的制备工艺并考察其体外释放特性。方法:采用亲水凝胶骨架与薄膜包衣控释技术制备溴新斯的明缓释片,并对处方进行体外累积释放度的考察。结果:所研制的缓释片能够持续释药12 h,释放规律符合一级释放方程。结论:溴新斯的明缓释片制备工艺合理,具有良好的缓释效果,符合设计要求。Objective：To optimize the preparation of neostigmine bromide sustained-release tablets and to study its in-vitro drug release property.Methods：Hydrophilic matrix tablets and film coating were used to prepare neostigmine bromide sustained-release tablets and the in-vitro accumulated release rate of the formula was studied.Results：The releasing of the sustained-release tablets prepared here lasts 12 hours and fits the first-order releasing equation.Conclusion：The neostigmine bromide sustained release tablets obtain good releasing and are consistent with specification.

关 键 词：溴新斯的明 缓释片 释放 

分 类 号：R943[医药卫生—药剂学]