叶酸对H型高血压同型半胱氨酸水平和主要心血管事件的影响  

The effect of folic acid on plasma homocysteine and main cardiovascular events for patients with hyperhomocysteinima-related hypertention

作　　者：徐中林[1] 赵义发[1] 吴兰兰[1] 

机构地区：[1]重庆市第九人民医院心内科,重庆400700

出　　处：《重庆医科大学学报》2011年第6期731-733,共3页Journal of Chongqing Medical University

摘　　要：目的:探讨叶酸干预治疗对H型高血压患者血浆同型半胱氨酸(Homocysteine,Hcy)水平和主要心血管事件(非致死性心肌梗塞、脑梗塞及心血管疾病死亡)的影响。方法:将264例高血压合并高Hcy的H型高血压患者随机分为试验组124例和对照组140例,试验组和对照组均强调生活方式的改变和正规药物降压等常规治疗,试验组在常规治疗的基础上同时给予口服叶酸5 mg qd。随访3个月后两组患者血浆Hcy水平的变化和整个随访期间两组无主要心血管事件生存率情况。结果:与治疗前及对照组相比,试验组叶酸治疗3个月后血浆Hcy水平显著下降(P<0.05),而对照组无明显变化。整个随访期间对照组无主要心血管事件生存率为85%,试验组为93.5%,2组间差异有统计学意义(P<0.05)。结论:叶酸干预治疗可以明显降低H型高血压患者血浆Hcy水平并增加无主要心血管事件生存率。Objective：To evaluate the effect of folic acid on plasma homocysteine and main cardiovascular events in patients with hyperhomocysteinima-related hypertention.Methods：264 patients with hyperhomocysteinima-related hypertention were randomly divided into two groups.All patients in the two groups were given the routine treatment with antihypertensive drug.124 patients in the treatment group were given oral folic acid（5 mg/d）in addition to routine treatment.Results：The plasma homocysteine in treatment group was reduced significantly compared with that ofpretreatment and control group after folic acid administration for 3 months（P〈0.05）.The survival rates of none cardiovascular events was 85% in control group and 93.5% in treatment group（P〈0.05）.Conclusion：The treatment of oral folic acid reduces the level of plasma homocysteine and increases the survival rates of none cardiovascular events in patients with hyperhomocysteinima-related hypertention.

关 键 词：叶酸 H型高血压 同型半胱氨酸 心血管事件 

分 类 号：R544.1[医药卫生—心血管疾病]