Twist及Akt2在甲状腺乳头状癌中的表达及意义  

Expression of Twist and Akt2 in papillary thyroid carcinoma and its significance

作　　者：王士娜[1] 马静[2] 滕猛[1] 宦大为[1] 王翠芳[1] 

机构地区：[1]沈阳医学院奉天医院病理科 [2]沈阳市第四人民医院麻醉科,辽宁110024

出　　处：《中国组织化学与细胞化学杂志》2011年第1期56-59,共4页Chinese Journal of Histochemistry and Cytochemistry

摘　　要：目的探讨Twist、Akt2在甲状腺乳头状癌中的表达和相互关系。方法应用免疫组化方法,对60例甲状腺乳头状癌、10例结节性甲状腺肿进行Twist、Akt2表达的研究。结果甲状腺乳头状癌Twist及Akt2阳性表达率分别为81.67%(49/60)及60.00%(36/60),结节性甲状腺肿Twist及Akt2阳性表达率分别为0.00%(0/10)及10.00%(1/10),前者与后者相比差异有统计学意义(P<0.05);Twist及Akt2在甲状腺乳头状癌中的表达水平与病人的年龄及原发肿瘤分期无关,但与有无淋巴结转移相关(P<0.05),且Akt2的表达在T3,4期肿瘤及T1,2期肿瘤相比也具有显著性(P<0.05);Twist及Akt2的表达呈正相关(r=0.492,P=0.000)。结论在大多数甲状腺乳头状癌的上皮细胞中都存在Twist及Akt2的过表达,其淋巴结转移的发生与Twist及Akt2过表达或功能的不正常可能有密切的关系;Twist与Akt2的表达呈正相关。Objective To study the expression of Twist,Akt2 in papillary thyroid carcinoma（PTC）and their relationship with clinicopathological factors.Methods Twist and Akt2 were measured in papillary thyroid carcinoma（n=60） and nodular goiter（n=10）by immunohistochemical staining.Results In PTC,positive rates of Twist and Akt2 were 81.7%（49/60） and 60.0%（36/60）;in nodular goiter,they were 0.0%（0/10）and 10.0%（1/10）,respectively.There were stutistically significant differences.The positive expressions of Twist and Akt2 were both related to lymph node metastasis.Besides,the difference in the positive expression of Akt2 between the stages T3,4 and the stages T1,2 was also statistically significant.The expression of Twist showed a positive correlation with Akt2.Conclusion Twist and Akt2 expressions in are increased PTC.They are both correlated with lymph node metastasis and Akt2 is related with the stage of the carcinoma.The expression of Twist shows a positive correlation with that of Akt2.

关 键 词：甲状腺癌 甲状腺乳头状癌 TWIST AKT2 EMT 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]