16例甲型H1N1流感危重症确诊病例临床特征及治疗情况分析  

Clinical feature and therapy effect analysis of 16 cases of critical A H1N1 influenza

作　　者：周菁[1] 许飞[1] 张伟[1] 

机构地区：[1]南昌大学第一附属医院呼吸内科,南昌330006

出　　处：《重庆医科大学学报》2011年第7期883-885,共3页Journal of Chongqing Medical University

摘　　要：目的：综合分析甲型H1N1流感危重症的临床特征和治疗效果。方法：动态观察16例确诊甲型H1N1流感危重症病例的临床特征,对诊治情况进行回顾性分析。结果：16例危重症患者中,男性6例,女性10例,16例均发生肺部感染,所有患者均有发热,平均发热持续3.64 d入院,咳嗽、乏力、肌肉酸痛、胸闷、恶心等全身症状较多;早期的抗病毒治疗及短期3~7 d的小剂量糖皮质激素及晚期的提高免疫力治疗及广谱包括真菌的抗菌药物使用在部分病例中获得成功,多科医生及护士的密切合作和精细治疗十分重要。结论：甲型H1N1流感病毒致病力及致死率与季节性流感相似,危重症需要早期的抗病毒治疗和后期的抗菌治疗及精细的加强治疗以提高存活率。Objective：To conduct aggregate analysis of the clinical features and therapy effects of critical A H1N1 influenza cases.Methods：The clinical features of 16 cases of critical A H1N1 influenza were dynamically observed,and the therapy effects were retrospectively analyzed.Results：In the 16 cases,6 were male and the others were female;all of the 16 cases had lung infection.All the cases had fever,and the average persistence time from onset to admission was 3.64 days;the general symptoms were common,including cough,hypodynamia,muscle ache,chest distress,and nausea.Early anti-virus and 3-7days of low-dose glucocorticoids therapies,and immunity enhancement and antibacterial therapies in later period gained success in some cases.The intimate cooperation of multi-department staff and refined therapy were very important.Conclusion：The virulence and mortality of A H1N1 influenza is similar to seasonal influenza.As to critical A H1N1 influenza cases,we should afford inchoate anti-virus,and antibacterial therapy and subtle intensive therapy in later period to improve survival.

关 键 词：甲型H1N1流感危重症 奥司他韦 甲型H1N1流感抗体血浆 糖皮质激素 丙种球蛋白 机械通气 

分 类 号：R322.8[医药卫生—人体解剖和组织胚胎学]