艾滋病并发马尔尼菲青霉病40例死亡病例特点分析  

Clinical Analysis of 40 Cases Died of AIDS with Penicilliosis Marneffe: A Report

作　　者：蒙江明[1] 张云辉[2] 胡小翠[1] 李军[2] 

机构地区：[1]南宁市第四人民医院内科 [2]解放军第302医院

出　　处：《医学研究杂志》2011年第8期61-63,共3页Journal of Medical Research

基　　金：全球基金中国艾滋病项目(CHN-304-G03-H);广西壮族自治区医药卫生自筹经费计划课题(Z2010159)

摘　　要：目的总结艾滋病合并马尔尼菲青霉病死亡病例的特点，提高对该病的认识。方法对2008年3月-2010年6月笔者医院收治的40例艾滋病合并马尔尼菲青霉病死亡患者的住院资料进行回顾性分析。结果患者外周血CD4＋T淋巴细胞平均计数普遍低下（56．46±25．86个／微升），以发热、贫血、消瘦、咳嗽、咳痰、皮疹、浅表淋巴结肿为主要表现，同时合并其他多种机会感染或疾病，以肺部其他细菌感染、口腔念珠菌病、结核病、带状疱疹、消化道出血多见。晚期治疗效果不好。结论马尔尼菲青霉病是南方艾滋病患者常见死亡的原因之一，主要发生于CD4＋T淋巴细胞〈100个／微升的患者。在南方对艾滋病患者进行PSM的常规普查是很有必要的，这样才能早发现、早诊断、早抗病毒、抗真菌治疗，有效降低患者的病死率。Objective To summarize features of death cases of AIDS with Penicillium marneffei and to improve the knowledge of the disease. Methods The clinical data of 40 death cases with AIDS with Penicillium marneffei hospitalized patients from March 2008 to June 2010 were retrospectively analyzed. Results The major symptoms of death cases of AIDS with Penicillium marneffei were fever,anemia, loss of weight,cough, expectoration, skin rash,superficial lymph nodes. It was found coincidentally following. The most common complications were bacterial infection,oral candidiasis,herpes zoster,tuberculosis and digestive hemorrhage. The clinical effect of treating advanced patients was not quite good. Conclusion Penieilliosis Marneffei is one of the main reasons of the death caused by AIDS in south China, typically occurs when CD4＋ T cell counts fall below 100μl. General screening of Penieilliosis Marneffei for AIDS patients in the south China is very necessary in which we can diagnose and cure AIDS with Penicillinm marneffei early and reduce the death rate.

关 键 词：艾滋病 马尔尼菲青霉病 死亡原因 

分 类 号：R519[医药卫生—内科学]