频发性室性期前收缩对扩张型心肌病患者炎症状态和心功能的影响  

The Influence of Frequent Ventricular Premature Contractions on the Inflammatory Status and Cardiac Function in Patients with Dilated Cardiomyopathy

作　　者：石少波[1] 杨波[1] 梁锦军[1] 李鹏飞[1] 刘凯[1] 王欣欣[1] 

机构地区：[1]武汉大学人民医院心内科,湖北省心血管病临床研究中心,心血管病湖北省重点实验室,430060

出　　处：《医学研究杂志》2011年第8期67-69,共3页Journal of Medical Research

基　　金：湖北省"十一五"重大科技攻关项目(2006A301A04);湖北省自然科学基金优秀群体项目(2007ABC011);武汉大学"中央高校基本科研业务费专项资金"资助项目(4104006)

摘　　要：目的探讨频发性室性期前收缩(PVCs)对扩张型心肌病(DCM)患者炎症状态和心功能的影响。方法将188例DCM患者分为DCM+PVCs组(128例)以及DCM组(60例),比较两组患者的hs-CRP水平,NYHA心功能分级,N端脑钠肽前体(NT-proBNP)水平,左心室舒张末内径(LVEDD),左心室射血分数(LVEF)的差异。结果 DCM+PVCs组hs-CRP水平(4.21±2.39mg/L),DCM组(3.75±2.25mg/L),两组hs-CRP水平比较无统计学差异(P>0.05);DCM+PVCs组与DCM组相比,NYHA分级更高(3.02±0.62级vs 2.68±0.66级,P<0.05),NT-proBNP浓度≥1800pg/m l者更多(105/128 vs 37/60,P<0.01),LVEDD更大(65.65±7.82mm vs 59.63±11.34mm,P<0.01),LVEF更低(34.32%±6.79%vs 38.02%±7.55%,P<0.05)。结论 DCM伴发PVCs患者比无PVCs患者心功能分级更高,左心室功能更差,提示临床应足够重视PVCs的诊断和治疗,可改善患者心功能水平以及预后。Objective To investigate the influence of frequent ventricular premature contractions on the inflammatory status and cardiac function in patients with dilated cardiomyopathy （ DCM）. Methods We compared the differences of hs - CRP level, NYHA classes, NT -proBNP level,left ventricular end diastolic diameter（LVEDD） and left ventricular ejection fraction（LVEF） between DCM accompanied with PVCs group and non - accompanied with PVCs group. Results There was no significant difference in hs - CRP level between DCM accompanied with PVCs group and non -accompanied with PVCs group （4.21 ± 2.39mg,/L vs 3.75 ± 2.25mg/L,P 〉 0.05 ）. NYHA classes were higher（3.02 ± 0.62 class vs 2.68 ± 0.66 class, P 〈 0.05 ）. The number of patients whose NT - proBNP concentration ≥ 1800pg/ml were more（ 105/128 vs 37/60, P 〈 0.01 ）. LVEDD was strikingly greater（ 65.65 ± 7.82mm vs 59.63± 11.34mm, P 〈 0.01 ）. LVEF was lower（34.32% ± 6.79% vs 38.02% ± 7.55% , P 〈 0.05 ）. Conclusion Heart failure is more serious and left ventricular function is worse in patients of dilated cardiomyopathy with PVCs than those without PVCs,which suggestes that adequate attention should be given to PVCs clinical diagnosis and treatment.

关 键 词：频发性室性期前收缩 扩张型心肌病 超敏C反应蛋白 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]