麻疹患儿感染早期肝损伤与细胞免疫分析  

Early Liver Damage and Cellular Immune in Small Children with Measles

作　　者：陈刚[1] 蒋雨虹[1] 徐爱芳[1] 李宏波[1] 章松平[1] 

机构地区：[1]杭州市第六人民医院检验科,310014

出　　处：《医学研究杂志》2011年第8期124-126,共3页Journal of Medical Research

摘　　要：目的研究麻疹患儿血清酶学和细胞免疫的变化。方法用流式细胞仪对167例麻疹患儿外周血T淋巴细胞亚群(CD3+细胞、CD4+细胞、CD8+细胞)进行检测,血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)检测采用日立7600全自动生化分析仪;另选43例门诊体检者作为正常对照组。结果麻疹患儿血清ALT水平显著高于对照组(P<0.05),血清AST水平显著高于对照组(P<0.01)。麻疹患儿CD8+细胞数显著高于对照组(P<0.05),麻疹组与对照组间CD3+细胞和CD4+细胞数差异则无统计学意义。结论外周血T淋巴细胞和血清酶学水平有助于监测麻疹病毒感染机体免疫状态和肝损伤。Objective To study the changes of plasma enzymology and cellular immune in small children with measles. Methods CD3 cells,CD4 cells and CD8 cells were counted with flow cytometry in all patients（n = 167） and Outpatient service medical as normal controls. While ALT and AST were detected with chemistry analyzer. Results Compared with the control group,ALT and AST in small children patients with measles - infection was significantly increased. Compared with the control group,the counts of CD8 cells in patients with measles - infection was significantly increased. While there was no difference in the counts of the CD3 cells and CD4 cells between measles - infection groups and normal groups （ P 〉 0.05 ）. Conclusion To understand the changes of plasma enzymology and cellular immune in small children with measles may help to evaluate the patients＇ liver damage and cellular immune.

关 键 词：麻疹 血清酶学 细胞免疫 

分 类 号：R373.11[医药卫生—病原生物学]